Apr 23, 2020

Impact of biotic and abiotic factors on competitive interactions between Pseudomonas aeruginosa and Staphylococcus aureus

BioRxiv : the Preprint Server for Biology
Selina Niggli, R. Kümmerli

Abstract

Bacterial communities in the environment and in infections are typically diverse, yet we know little about the factors that determine interspecies interactions. Here, we apply concepts from ecological theory to understand how biotic and abiotic factors affect interaction patterns between the two opportunistic human pathogens Pseudomonas aeruginosa and Staphylococcus aureus, which often co-occur in polymicrobial infections. Specifically, we conducted a series of short- and long-term competition experiments between P. aeruginosa PAO1 (as our reference strain) and three different S. aureus strains (Cowan I, 6850, JE2) at three different starting frequencies and under three different environmental (culturing) conditions. We found that the competitive ability of P. aeruginosa strongly depended on the strain background of S. aureus, whereby P. aeruginosa dominated against Cowan I and 6850, but not against JE2. In the latter case, both species could end up as winners depending on conditions. Specifically, we observed strong frequency-dependent fitness patterns, including positive frequency dependence, where P. aeruginosa could dominate JE2 only when common, but not when rare. Finally, changes in environmental (culturing) conditions fu...Continue Reading

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Mentioned in this Paper

DLG4
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Genes
SON protein, human
TLK2 gene
Candidate Disease Gene
Intellectualization
Iron Deficiency
PPM1D gene

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