Meta-analysis of adjuvant therapy following curative surgery for periampullary adenocarcinoma

The British Journal of Surgery
A AcharyaA Z Khan

Abstract

Periampullary cancers are uncommon malignancies, often amenable to surgery. Several studies have suggested a role for adjuvant chemotherapy and chemoradiotherapy in improving survival of patients with periampullary cancers, with variable results. The aim of this meta-analysis was to determine the survival benefit of adjuvant therapy for periampullary cancers. A systematic review was undertaken of literature published between 1 January 2000 and 31 December 2015 to elicit and analyse the pooled overall survival associated with the use of either adjuvant chemotherapy or chemoradiotherapy versus observation in the treatment of surgically resected periampullary cancer. Included articles were also screened for information regarding stage, prognostic factors and toxicity-related events. A total of 704 titles were screened, of which 93 full-text articles were retrieved. Fourteen full-text articles were included in the study, six of which were RCTs. A total of 1671 patients (904 in the control group and 767 who received adjuvant therapy) were included. The median 5-year overall survival rate was 37·5 per cent in the control group, compared with 40·0 per cent in the adjuvant group (hazard ratio 1·08, 95 per cent c.i. 0·91 to 1·28; P = 0·...Continue Reading

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Apr 3, 2019·Tumori·Rosa FalconePaolo Marchetti
Jan 3, 2019·Minerva chirurgica·Victor Lopez-LopezPascual Parrilla
Feb 22, 2018·Journal of Gastrointestinal Cancer·Saphalta BaghmarViniyendra Pamecha
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Sep 30, 2021·Current Treatment Options in Oncology·Monica Patel, Nataliya V Uboha

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