Meta-analysis of alcohol induced gut dysbiosis and the resulting behavioral impact

Behavioural Brain Research
Nayab QamarSulie L Chang

Abstract

About 99% of the unique genes and almost half of the cells found in the human body come from microbes including bacteria, archaea, fungi, and viruses. Collectively these microorganisms contribute to the microbiome and often reside in the gut. The gut microbiome plays an important role in the body and contributes to digestive health, the immune system, and brain function. The gut microbiome interacts with the central nervous system through the vagal pathways as well as the endocrine or immune pathways. Changes in the proportion or diversity of the microbiota can have an impact on normal physiology and has been implicated in inflammation, depression, obesity, and addiction. Several animal studies suggest the involvement of gut microbiome in the regulation of pain, emotion, and cognition. Alcoholism has been linked with gut microbiome dysbiosis and thus can have deleterious effects on the gut-brain axis balance. Gut microbiome produces important metabolites such as gastrointestinal hormones, short chain fatty acids, precursors to the neuroactive compounds and neurotransmitters that impact the physiology and normal functioning of the body. The microbiome imbalance has been correlated with behavioral changes and alcohol dependence i...Continue Reading

Citations

Jan 29, 2021·Addiction Biology·Fernando EzquerYedy Israel
Feb 19, 2021·Pharmacological Reviews·Mariana Angoa-Pérez, Donald M Kuhn
Jun 20, 2021·Journal of Affective Disorders·Santosh ThapaChadi A Calarge
Jul 25, 2021·International Journal of Molecular Sciences·Javier Calleja-CondeJose Antonio López-Moreno
Jul 3, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Manni Luthra-Guptasarma, Purnananda Guptasarma
Nov 30, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xiangqian LiuSulie L Chang

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