Meta-analysis of association between GSTM1 gene polymorphism and cervical cancer

Asian Pacific Journal of Tropical Medicine
Ying Liu, Liang-Zhi Xu

Abstract

To investigate association between glutathione S-transferases (GSTs) and cervical cancer. Published literature from PubMed, EMBASE, and other databases were retrieved. All studies evaluating the association between GSTM1/GSTT1 polymorphisms and cervical were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed- or random-effects model. A total of 15 case-control studies were included in the meta-analysis of GSTM1 genotypes (1,825 cases and 2,104 controls). The overall result showed that the association between GSTM1 null genotype and risk for cervical cancer was statistically significant (OR=1.53, 95%CI=1.18-2.00). Great heterogeneity was found between studies. Subgroup analysises were performed based on smoking and ethnicity. Our results showed that smokers with null GSTM1 genotype had higher risk of cervical cancer (OR=1.56, 95%CI=1.01-2.41). For the ethnicity stratification, significant increased risk of null GSTM1 genotype was found in Chinese and Indian population, but no increased risk in other population. This meta-analysis provides strong evidence that the GSTM1 null genotype is associated with the development of cervical cancer, and especially in Chinese and Indian population, a...Continue Reading

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Citations

Oct 24, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanan Zhang, Chibo Liu
Oct 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hong-Li SunKai Ma
Jan 21, 2016·The Journal of Obstetrics and Gynaecology Research·Salva Sadat MostafaviFoozieh Javadi
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jie ChenLe-Qun Li
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Rui LiuQiang Zhou
Dec 24, 2014·Biochimica Et Biophysica Acta·Cesira FoppoliM Perluigi
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ewa DrozdBeata Gruber-Bzura
Oct 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jing NiQiang Wu
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Archana Krishna MurthyK P Suresh
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Anita SharmaJoginder Kumar Sharma

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