Meta-analysis of biochemical and patient-level effects of calcimimetic therapy

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
G F M StrippoliJ C Craig

Abstract

Many randomized trials have now evaluated the effects of calcimimetics in patients with chronic kidney disease and secondary hyperparathyroidism (SHPT) on standard therapy with vitamin D and/or phosphate binders. We conducted a meta-analysis to evaluate outcomes of therapy with these novel agents. MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and conference proceedings were searched for randomized controlled trials evaluating any calcimimetic against placebo or another agent in predialysis or dialysis patients with chronic kidney disease. Data were extracted for all relevant patient-centered and surrogate outcomes. Analysis was by means of a random-effects model, and results are expressed as relative risk or weighted mean difference (WMD) with 95% confidence intervals (CIs). Eight trials (1,429 patients) were identified that compared a calcimimetic agent plus standard therapy with placebo plus standard therapy. End-of-treatment values for parathyroid hormone (4 trials; 1,278 patients; WMD, -290.49 pg/mL; 95% CI, -359.91 to -221.07), serum calcium (3 trials; 1,201 patients; WMD, -0.85 mg/dL; 95% CI, -1.14 to -0.56), serum phosphorus (3 trials; 1,195 patients; WMD, -0.29 mg/dL; 95% CI, -0.50 to -0.08), and calcium x p...Continue Reading

References

Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J Simes
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M WangY Pei
Oct 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Q QiH H Malluche
Feb 1, 1995·JAMA : the Journal of the American Medical Association·K F SchulzD G Altman
Dec 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M AvramP Fein
Feb 6, 1998·BMJ : British Medical Journal·M Egger, G D Smith
Feb 14, 1998·Kidney International·D J Sherrard
Aug 27, 1999·JAMA : the Journal of the American Medical Association·B M PsatyE H Wagner
Aug 27, 1999·JAMA : the Journal of the American Medical Association·R Temple
Apr 20, 2001·JAMA : the Journal of the American Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Santhi K GaneshFriedrich K Port
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·William G GoodmanJack W Coburn
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·L Darryl QuarlesDavid A Bushinsky
May 20, 2003·Kidney International. Supplement·Pablo Ureña, João M Frazão
May 20, 2003·Kidney International. Supplement·Maria Paz MarcoElvira Fernández
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jan 20, 2004·Seminars in Nephrology·Catherine Stehman-Breen
Feb 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin J MartinUNKNOWN Bone Turnover Work Group
Apr 9, 2004·The New England Journal of Medicine·Geoffrey A BlockWilliam G Goodman
May 6, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hartmut H MallucheMarie-Claude Monier-Faugere
May 22, 2004·Journal of the American Society of Nephrology : JASN·Lawrence P McMahonUNKNOWN Slimheart Investigators Group
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Oct 13, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Richard BorrowsDavid Taube
Nov 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert Z HarrisJohn T Sullivan
Dec 24, 2004·Journal of the American Society of Nephrology : JASN·Bryan KestenbaumDennis L Andress
Jul 22, 2005·The New England Journal of Medicine·Christoph WannerUNKNOWN German Diabetes and Dialysis Study Investigators

❮ Previous
Next ❯

Citations

Apr 1, 2009·The New England Journal of Medicine·Giovanni F M Strippoli, Jonathan C Craig
Nov 6, 2012·The New England Journal of Medicine·Vlado Perkovic, Bruce Neal
Feb 13, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Suetonia C PalmerGiovanni F M Strippoli
Jan 1, 2008·International Journal of Nephrology and Renovascular Disease·James B Wetmore, L Darryl Quarles
Aug 22, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Stuart M SpragueGordon Wong
Mar 26, 2013·Nutrients·Masanori AbeMasayoshi Soma
Mar 3, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·José PortolésRafael Selgas
Oct 30, 2008·Nature Clinical Practice. Nephrology·James B Wetmore, L Darryl Quarles
Dec 2, 2008·Expert Opinion on Drug Metabolism & Toxicology·Piergiorgio MessaBrigida Brezzi
Apr 15, 2009·The American Journal of the Medical Sciences·Lauren M CzosnowskiRobert B Canada
Feb 12, 2011·Néphrologie & thérapeutique·Pablo Urena Torres
Mar 17, 2011·Advances in Chronic Kidney Disease·Donald A Molony, Brett W Stephens
Jun 3, 2008·American Journal of Surgery·Han-Hsiang ChenTsen-Long Yang
Jan 4, 2007·Advances in Chronic Kidney Disease·Eric W Young
May 30, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajeev NarayanKevin C Abbott
Oct 19, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Theresa I ShiremanL Darryl Quarles
Jul 1, 2009·Nephrology·Sankar D NavaneethanGiovanni F M Strippoli
Jul 1, 2009·Nephrology·Denise V O'Shaughnessy, Grahame J Elder
Aug 28, 2009·Seminars in Dialysis·Raymond VanholderZiad A Massy
Jul 4, 2009·Seminars in Dialysis·Pieter Evenepoel
Sep 22, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kentaro NakaiMasafumi Fukagawa
Feb 23, 2011·Seminars in Dialysis·David W Johnson
Nov 15, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Assia Ghani, Prudence Baxter
Dec 10, 2014·The Cochrane Database of Systematic Reviews·Angela E BallingerGiovanni F M Strippoli
Feb 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Douglas M SilversteinKathleen Moylan
Jul 3, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Georg Schlieper, Jürgen Floege
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni Fm Strippoli
Sep 13, 2012·European Journal of Pediatrics·Betti Schaefer, Elke Wühl
Oct 13, 2011·Journal of Medical Economics·Andrew LeeDavid Diakun
Jun 15, 2007·Current Opinion in Nephrology and Hypertension

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Pablo Ureña Torres
Clinical Journal of the American Society of Nephrology : CJASN
Piergiorgio MessaFrancesco Locatelli
The Cochrane Database of Systematic Reviews
G F M StrippoliJ C Craig
Mini Reviews in Medicinal Chemistry
Francesco LocatelliGiuseppe Pontoriero
© 2022 Meta ULC. All rights reserved