Meta-analysis of brain and cranial size in schizophrenia

Schizophrenia Research
K E WardS C Schulz

Abstract

Several meta-analyses are presented that address the issue of brain and/or cranial size reductions in schizophrenia. Separate meta-analyses were conducted for brain size (n = 27 studies), intracranial size (n = 18) or extracranial size (n = 8). For each meta-analysis, the weighted composite effect size (d) was tested for statistical significance (the direction of the effect size was negative if patients with schizophrenia had smaller structure size than controls). The influence of several potential modifiers of effect size (age, methods, region, gender) was individually evaluated. The composite effect sizes for studies of brain, intracranial and extracranial measures were d = -0.26, (p < 0.0001), d = -0.18, (p = 0.0012), and d = +0.14, (p = 0.16), respectively. Thus, the review found evidence for a small, but statistically significant reduction in brain and intracranial size in schizophrenia, but no evidence for a reduction in extracranial size. Studies based on axial image slices had significantly larger effects (d = -0.60) than the studies based on sagittal images (d = -0.09) (chi(2) = 14.0, p = 0.0002). In summary, the findings clearly support a small yet highly significant reduction of brain and intracranial size in schizop...Continue Reading

References

Feb 1, 1979·Journal of the Neurological Sciences·H J KretschmannH J Löblich
Mar 1, 1979·Journal of Autism and Developmental Disorders·J H White, J B Rust
Jan 1, 1992·Schizophrenia Bulletin·R M MurrayS W Lewis
May 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·J D Van Horn, I C McManus
Apr 1, 1992·Clinical Imaging·R N Sener, J R Jinkins
Mar 1, 1992·Archives of General Psychiatry·R B ZipurskyA Pfefferbaum
Oct 1, 1991·Schizophrenia Research·B T Woods, D Yurgelun-Todd
Oct 1, 1991·Archives of General Psychiatry·T L JerniganD L Braff
May 1, 1991·Psychiatry Research·S B SchwarzkopfT Mitra
Sep 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·G H Jones, J E Lewis
Jan 1, 1991·Schizophrenia Bulletin·W M GroveC Medus
Nov 1, 1990·Archives of General Psychiatry·S HeckersH Beckmann
Nov 1, 1990·The American Journal of Psychiatry·P E BartaL E Tune
Jan 1, 1990·Brain, Behavior and Evolution·J M CheverudM Vannier
Jan 1, 1990·Schizophrenia Bulletin·A PfefferbaumR B Zipursky
Jan 1, 1990·Schizophrenia Bulletin·H A NasrallahJ A Coffman
Jan 1, 1989·Schizophrenia Bulletin·M F GreenF Kharabi
Apr 1, 1989·Brain Research. Developmental Brain Research·B Zimmerberg, J M Reuter
Aug 1, 1989·Archives of General Psychiatry·G D PearlsonL E Tune
Apr 1, 1989·The American Journal of Psychiatry·R L SuddathD R Weinberger
Nov 1, 1988·Schizophrenia Research·M Uematsu, H Kaiya
Feb 1, 1988·The American Journal of Psychiatry·R C SheltonD R Weinberger
Jun 1, 1988·Archives of General Psychiatry·J R KelsoeD R Weinberger
Dec 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·B Pakkenberg
Jan 1, 1987·Psychiatry Research·R C SmithM Calderon
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jul 1, 1987·Archives of General Psychiatry
Nov 1, 1986·Brain Research·H T Epstein
Jan 1, 1987·American Journal of Medical Genetics·P Meinecke
Feb 1, 1986·Archives of General Psychiatry·N AndreasenJ H Crossett
Nov 1, 1985·Acta Psychiatrica Scandinavica·R J MathewW H Wilson
May 1, 1974·American Journal of Physical Anthropology·L Van Valen
Oct 1, 1973·Archives of Disease in Childhood·J Dobbing, J Sands
Sep 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·R Rosenthal, L B Bigelow

❮ Previous
Next ❯

Citations

Sep 12, 2000·Mental Retardation and Developmental Disabilities Research Reviews·A L ReissM Haberecht
Sep 9, 2006·European Archives of Psychiatry and Clinical Neuroscience·Nicola AndreonePaolo Brambilla
Feb 13, 2001·Biological Psychiatry·L C Konick, L Friedman
Jan 23, 1999·Biological Psychiatry·L D Selemon, P S Goldman-Rakic
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Albert Hung Choy Wong, Hubert H M Van Tol
Apr 17, 2002·Schizophrenia Research·Peter F BuckleyGeorge Jaskiw
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Sep 27, 2003·Schizophrenia Research·Paul J HarrisonJohn R Geddes
Aug 5, 1998·Schizophrenia Research·A B WhitworthW W Fleischhacker
Jun 22, 1999·Schizophrenia Research·E A HogeS C Schulz
Mar 9, 2000·Schizophrenia Research·L FriedmanP Buckley
Oct 3, 1999·Schizophrenia Research·B Baumann, B Bogerts
Dec 29, 2000·The Australian and New Zealand Journal of Psychiatry·P D McGorry
May 20, 2003·Neurotoxicity Research·Jenny WalkerRobin M. Murray
Mar 10, 2007·Brain : a Journal of Neurology·Motoaki NakamuraMartha E Shenton
Sep 17, 2004·Cerebral Cortex·Katherine L NarrPaul M Thompson
Aug 6, 2011·Cerebral Cortex·P ShawJ Giedd
Jun 6, 2007·Schizophrenia Bulletin·Raquel E GurStephen M Lawrie
Mar 31, 2009·Schizophrenia Bulletin·Angus W MacDonald, S Charles Schulz
Oct 9, 2012·Schizophrenia Bulletin·Sander V HaijmaRené S Kahn
Sep 23, 2011·Genes & Development·Joshua J BuchmanLi-Huei Tsai
May 11, 2006·The Australian and New Zealand Journal of Psychiatry·Mark TurnerRoger Mulder
Jul 23, 1999·Annals of the New York Academy of Sciences·J R Stevens
Apr 21, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M M WarwickE C Johnstone
Oct 1, 2006·Indian Journal of Psychiatry·Savita MalhotraMehak Kapoor
Aug 8, 2012·International Journal of Yoga·N Gangadhar Bangalore, Shivarama Varambally
Jan 15, 2014·Molecular Autism·Jillian C SullivanAyla Humphrey
Feb 15, 2002·Lancet·Kieran C Murphy
Mar 24, 2010·Radiology·Nivedita AgarwalPerry F Renshaw
May 5, 2012·Indian Journal of Psychiatry·Shivarama VaramballyBangalore N Gangadhar

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