PMID: 26320506Sep 1, 2015Paper

Meta-Analysis of Circulating Endothelial Cells and Circulating Endothelial Progenitor Cells as Prognostic Factors in Lung Cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Min YuJuan Jiang

Abstract

The aim of this study was to analyze the prognostic implications of pretreatment circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) for the survival of patients with lung cancer. Relevant literature was identified using Medline and EMBASE. Patient clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with CEC and CEPC positive rates before treatment were extracted. STATA 12.0 was used for our analysis and assessment of publication bias. A total of 13 articles (8 for CEC and 5 for CEPC, n=595 and n=244) were pooled for the global meta-analysis. The odds ratio (OR) for OS predicted by pretreatment CECs was 1.641 [0.967, 2.786], while the OR for PFS was 1.168 [0.649, 2.100]. The OR for OS predicted by pretreatment CEPCs was 12.673 [5.274, 30.450], while the OR for PFS was 4.930 [0.931, 26.096]. Subgroup analyses were conducted according to clinical staging. Odds ratio (OR) showed the high level of pretreatment CECs only correlated with the OS of patients with advanced lung cancer (stage III-IV). High counts of CECs seem to be associated only with worse 1-year OS in patients with lung cancer, while high level of pretreatment CEPCs correlate with both wors...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jul 28, 2001·BMJ : British Medical Journal·D G Altman
Nov 5, 2002·Nature Reviews. Cancer·Shahin RafiiBeate Heissig
Oct 4, 2005·Journal of Molecular and Cellular Cardiology·Carmen UrbichStefanie Dimmeler
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettGregory Y Lauwers
Nov 18, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Joseph Treat
Sep 2, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Matteo PirroElmo Mannarino
Jan 29, 2008·Journal of Thrombosis and Haemostasis : JTH·E ShantsilaG Y H Lip
Feb 16, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Gian Paolo FadiniAngelo Avogaro
Apr 24, 2008·Journal of Thrombosis and Haemostasis : JTH·E Shantsila, G Y H Lip
Aug 12, 2008·Journal of Vascular Surgery·Andreas SteinIlka Ott
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrizia MancusoFrancesco Bertolini
Jan 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Makoto KawaishiFumiaki Koizumi
Feb 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Krisztina BogosBalazs Dome
Jan 15, 2010·Neoplasia : an International Journal for Oncology Research·Jeanine M RoodhartEmile E Voest
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·G SchillaciE Mannarino
Jul 7, 2011·Stem Cells·Juan M Melero-Martin, Andrew C Dudley
Sep 20, 2011·Journal of Cancer Research and Clinical Oncology·Ryo MoritaHiroshi Ito
Jul 25, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Matteo PirroElmo Mannarino
Jan 21, 2014·Connective Tissue Research·William G Stetler-Stevenson, Noah Veis Gavil
Jul 20, 2014·Journal of Cancer Research and Clinical Oncology·Fadi NajjarGhassan Al-Massarani
Sep 23, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Alfredo Sánchez HernándezFrancisco García-Piñon

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