Meta-Analysis of Clinical Efficacy and Safety of Ligustrazine in the Treatment of Idiopathic Pulmonary Fibrosis

Evidence-based Complementary and Alternative Medicine : ECAM
Xiaozheng WuYunzhi Chen

Abstract

To systematically review the efficacy and safety of Ligustrazine in the treatment of idiopathic pulmonary fibrosis (IPF). The electronic literature databases (PubMed, EMbase, CNKI, WanFang database, and VIP) were retrieved through a computer to find out the randomized controlled trials (RCT) of Ligustrazine in the treatment of IPF according to the inclusion/exclusion criteria screening test. Cochrane's bias risk table was also used to evaluate the quality of the study and to extract effective data. RevMan 5.3 was used for statistical analysis. A total of 7 RCTs (a total of 366 patients, including 196 in experimental and 170 in control group). Compared with the control group, Ligustrazine could improve the clinical symptoms ([OR] = 2.20, 95% CI [1.40, 3.46], P=0.0006), lung function (VC % [MD] = 3.92, 95% CI [0.68, 7.17], P=0.02), (TLC% [MD] = 4.94, 95% CI [0.37, 9.52], P=0.03), the pulmonary diffusion function (DLCO % [MD] = 9.12, 95% CI [5.70, 12.55], P < 0.00001), and arterial blood gas analysis (PaO2 [MD] = 7.11, 95% CI [1.96, 12.25], P=0.007) (PaCO2 [MD] = -2.42, 95% CI [-4.36, -0.49], P=0.01) of IPF patients, respectively. However, FEV1/FVC % ([MD] = 9.37, 95% CI [-1.23, 19.97], P=0.08) and adverse reactions ([MD] = 0.35, ...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jun 7, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Edwin L Cooper
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Amy L OlsonKevin K Brown
Jun 6, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Amir Shmueli, Judith Shuval
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Sep 21, 2013·Annual Review of Pathology·Paul J WoltersKirk D Jones
Jul 16, 2015·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN Latin American Thoracic Association

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