Meta-analysis of diffusion tensor imaging studies in schizophrenia

Schizophrenia Research
Ian Ellison-Wright, Ed Bullmore

Abstract

The objective of the study was to identify whether there are consistent regional white matter changes in schizophrenia. A systematic search was conducted for voxel-based diffusion tensor imaging fractional anisotropy studies of patients with schizophrenia (or related disorders) in relation to comparison groups. The authors carried out meta-analysis of the co-ordinates of fractional anisotropy differences. For the meta-analysis they used the Activation Likelihood Estimation (ALE) method hybridized with the rank approach used in Genome Scan Meta-Analysis (GSMA). This system detects three-dimensional conjunctions of co-ordinates from multiple studies and permits the weighting of studies in relation to sample size. Fifteen articles were identified for inclusion in the meta-analysis, including a total of 407 patients with schizophrenia and 383 comparison subjects. The studies reported fractional anisotropy reductions at 112 co-ordinates in schizophrenia and no fractional anisotropy increases. Over all studies, significant reductions were present in two regions: the left frontal deep white matter and the left temporal deep white matter. The first region, in the left frontal lobe, is traversed by white matter tracts interconnecting th...Continue Reading

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