Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control

International Health
Joseph Nelson Siewe FodjoRobert Colebunders

Abstract

A high prevalence and incidence of epilepsy has been reported in onchocerciasis-endemic regions in Central and East Africa. There is compelling epidemiological evidence suggesting that this high burden is caused by onchocerciasis-associated epilepsy (OAE). We hypothesized that OAE had also occured in West African onchocerciasis foci. We searched PubMed, the African Journals Online platform and grey literature for population-based epilepsy studies in West African countries. Epilepsy and onchocerciasis prevalence data were extracted. The pre-control onchocerciasis endemicity in the study sites was estimated from historical data of onchocerciasis control programmes. The prevalence of epilepsy in different sites was analysed, taking into account onchocerciasis endemicity and the duration of control. The pooled prevalence of epilepsy in the West African study sites was 13.14 per 1000 (95% confidence interval 11.28-15.00). Higher pre-control endemicity and a shorter duration of onchocerciasis control were both associated with increased epilepsy prevalence (p<0.001). Two studies in Ivory Coast that provided detailed descriptions of persons with epilepsy in onchocerciasis-endemic settings revealed that most of them had features of OAE ...Continue Reading

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Citations

Feb 11, 2021·PLoS Neglected Tropical Diseases·Obiora A EneanyaPeter U Fischer
Jan 26, 2021·Journal of the Neurological Sciences·Jaime LunaPierre-Marie Preux
Jan 28, 2021·Brain Communications·Nolbert GumisirizaRobert Colebunders
Apr 13, 2021·Frontiers in Neurology·Ibitayo Abigail AdemuwagunEzekiel Adebiyi

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