Meta-analysis of five randomized clinical trials comparing sirolimus- versus paclitaxel-eluting stents in patients with diabetes mellitus

The American Journal of Cardiology
Feng ZhangJunbo Ge

Abstract

Recent data on drug-eluting stents have shown improved clinical outcomes in patients with diabetes mellitus. However, the relative efficacy and safety of sirolimus-eluting stents (SES) compared with paclitaxel-eluting stents (PES) remains controversial. Therefore, a meta-analysis of randomized trials was performed to compare SES with PES exclusively in patients with diabetes. The published research was scanned by formal searches of electronic databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials) from January 2001 to April 2009. All randomized trials involving head-to-head comparison of SES versus PES in patients with diabetes were examined for analysis. A total of 5 randomized trials were included in the present meta-analysis, involving 1,173 patients (594 in the SES group, 579 in the PES group). SES were significantly more effective in the reduction of target lesion revascularization (5.1% vs 11.4%, odds ratio [OR] 0.41, 95% confidence interval [CI] 0.26 to 0.64, p <0.001) and angiographic binary (> or =50%) restenosis (5.6% vs 16.4%, OR 0.30, 95% CI 0.19 to 0.48, p <0.001) compared to PES. In contrast, the differences between SES and PES were not statistically significant with respect to cardiac de...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 19, 1998·Journal of the American College of Cardiology·A AbizaidM B Leon
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Aug 18, 2005·The New England Journal of Medicine·Alban DibraUNKNOWN ISAR-DIABETES Study Investigators
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Adnan KastratiAlbert Schömig
Mar 1, 2008·The American Journal of Cardiology·Xilin YangPeter C Y Tong
Mar 18, 2008·Journal of Interventional Cardiology·Moo Hyun KimDo-Sun Lim
Jun 21, 2008·Journal of the American College of Cardiology·Ehtisham MahmudAnthony N Demaria
Aug 23, 2008·Journal of the American College of Cardiology·Seung-Whan LeeSeung-Jung Park
Sep 24, 2014·BMC Medical Research Methodology·Miriam Gjerdevik, Ivar Heuch

❮ Previous
Next ❯

Citations

Sep 29, 2012·Science Translational Medicine·Henk J BusscherDavid W Grainger
Jul 7, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Lisette Okkels JensenLeif Thuesen
Jul 7, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ryan SaadiNicole Ferko
Nov 2, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Rosli Mohd AliMartin Unverdorben
Jun 2, 2011·The American Journal of the Medical Sciences·Andreas SynetosChristodoulos Stefanadis
Apr 2, 2014·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Sebastian KufnerAdnan Kastrati
Apr 19, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giuseppe TarantiniCorrado Tamburino
May 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·William B Hillegass
Apr 19, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Xavier FreixaVladimír Džavík
Jun 6, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Moshe VardiDonald E Cutlip
Jun 27, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Walid HassanMohamed Shoukri
Oct 25, 2011·Journal of the American College of Cardiology·Fernando Alfonso, Cristina Fernandez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.