Meta-analysis of Foley catheter plus misoprostol versus misoprostol alone for cervical ripening

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Wenhang ChenShi Wu Wen

Abstract

The effectiveness of Foley catheter plus misoprostol for cervical ripening has not been convincingly shown in trials. To summarize the evidence comparing Foley catheter plus misoprostol versus misoprostol alone for cervical ripening. Embase, Medline, and Cochrane Collaboration databases were searched with the terms "Foley catheter," "misoprostol," "cervical ripening," and "labor induction." Randomized controlled trials comparing the methods of cervical ripening for delivery of a viable fetus were included. Study characteristics, quality, and outcomes were recorded. Random-effects models were used to combine data. Eight trials were included, with 1153 patients overall. In a pooled analysis of seven high-quality studies, the combination group had a decreased time to delivery (mean difference -2.36 hours, 95% confidence interval [CI] -4.07 to -0.66; P=0.007). Risk of chorioamnionitis was significantly increased in the combination group (risk ratio [RR] 2.07, 95% CI 1.04-4.13; P=0.04), and that of tachysystole with fetal heart rate changes was decreased (RR 0.58, 95% CI 0.38-0.91; P=0.02). Frequency of cesarean did not differ (P=0.77). The combined use of Foley catheter and misoprostol results in a reduced time to delivery, a reduc...Continue Reading

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Citations

Mar 22, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Wenhang ChenShi Wu Wen
Feb 12, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lía OrnatUNKNOWN Health Outcomes and Systematic Analyses (HOUSSAY) Research Group
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Aug 17, 2021·Geburtshilfe und Frauenheilkunde·Sven KehlPatrick Stelzl
Mar 3, 2020·American Journal of Perinatology·Rodney K EdwardsJennifer D Peck

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