Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth

JAMA Psychiatry
Chris H MillerIan H Gotlib

Abstract

Despite its high prevalence and morbidity, the underlying neural basis of major depressive disorder (MDD) in youth is not well understood. To identify in youth diagnosed as having MDD the most reliable neural abnormalities reported in existing functional neuroimaging studies and characterize their relations with specific psychological dysfunctions. Searches were conducted in PubMed and Web of Science to identify relevant studies published from November 2006 through February 2015. The current analysis took place from August 21, 2014, to March 28, 2015. We retained articles that conducted a comparison of youth aged 4 to 24 years diagnosed as having MDD and age-matched healthy controls using task-based functional magnetic resonance imaging and a voxelwise whole-brain approach. We extracted coordinates of brain regions exhibiting differential activity in youth with MDD compared with healthy control participants. Multilevel kernel density analysis was used to examine voxelwise between-group differences throughout the whole brain. Correction for multiple comparisons was performed by computing null hypothesis distributions from 10 000 Monte Carlo simulations and calculating the cluster size necessary to obtain the familywise error rat...Continue Reading

Citations

Feb 9, 2016·Diagnostics·Amer M BurhanFrank S Prato
Sep 1, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lara C Foland-RossIan H Gotlib
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Sarah D LichensteinErika E Forbes
Aug 10, 2016·Scientific Reports·Chen ZhangYiru Fang
Oct 30, 2016·Neuropharmacology·Katarzyna MisztalMarta B Wisniewska
Dec 15, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jennifer Y F Lau, Allison M Waters
Apr 13, 2017·Social Cognitive and Affective Neuroscience·Katerina StephanouBen J Harrison
May 30, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tiffany C HoTony T Yang
Oct 18, 2016·Clinical Psychological Science : a Journal of the Association for Psychological Science·Lauren B AlloyLyn Y Abramson
Jan 22, 2019·Translational Psychiatry·Liliana P CapitãoCatherine J Harmer
May 1, 2019·Journal of Child and Adolescent Psychopharmacology·Molly McVoyMartha Sajatovic
Mar 3, 2018·The Journal of School Health·Damali M Wilson, Deborah Gross
Oct 2, 2019·Frontiers in Behavioral Neuroscience·Kristen L EckstrandErika E Forbes
Apr 19, 2020·Brain Imaging and Behavior·Chuanjun ZhuoXueqin Song
Jun 2, 2020·Frontiers in Psychiatry·Qiangli DongLingjiang Li
Aug 28, 2020·Frontiers in Psychiatry·Xiaoming WangYuan Zhou
Mar 30, 2017·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Michelle M ReisingBruce E Compas
May 11, 2019·Child Development·Elysia Poggi DavisCurt A Sandman
May 28, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rajpreet ChahalAmanda E Guyer
Jan 7, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jie YangZhishun Wang
Nov 30, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shengnan WeiFei Wang

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