Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

Mechanisms of Ageing and Development
Janice S LeeJ Christopher Corton


Aging is associated with a loss of cellular homeostasis, a decline in physiological function and an increase in various pathologies. Employing a meta-analysis, hepatic gene expression profiles from four independent mouse aging studies were interrogated. There was little overlap in the number of genes or canonical pathways perturbed, suggesting that independent study-specific factors may play a significant role in determining age-dependent gene expression. However, 43 genes were consistently altered during aging in three or four of these studies, including those that (1) exhibited progressively increased expression starting from 12 months of age, (2) exhibited similar expression changes in models of progeria at young ages and dampened or no changes in old longevity mouse models, (3) were associated with inflammatory tertiary lymphoid neogenesis (TLN) associated with formation of ectopic lymphoid structures observed in chronically inflamed tissues, and (4) overlapped with genes perturbed by aging in brain, muscle, and lung. Surprisingly, around half of the genes altered by aging in wild-type mice exhibited similar expression changes in adult long-lived mice compared to wild-type controls, including those associated with intermedi...Continue Reading


Nov 24, 1977·Nature·T B Kirkwood
Apr 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T B Kirkwood, M R Rose
Jan 1, 1992·American Journal of Respiratory Cell and Molecular Biology·K ToriiT Ozawa
Jun 26, 1995·Biochemical and Biophysical Research Communications·R EdamatsuL Packer
Apr 12, 1994·Biochimica Et Biophysica Acta·D BoffoliS Papa
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
May 1, 1993·Journal of Neurochemistry·A C BowlingM F Beal
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Jan 19, 1999·Biochemistry and Molecular Biology International·M M EnglerH Nguyen
Jun 23, 1999·Journal of Neuroimmunology·S M Ye, R W Johnson
Jul 11, 2000·Nature Genetics·C K LeeT A Prolla
Sep 16, 2000·Journal of Epidemiology and Community Health·N Gouveia, T Fletcher
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
Jan 18, 2002·The Journal of Biological Chemistry·Anuradha WaghrayYong Q Chen
Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Igor DozmorovRichard A Miller
May 23, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Robert P ThomasB Mark Evers
May 24, 2003·The European Respiratory Journal. Supplement·P FischerJ van Wijnen
May 24, 2003·The European Respiratory Journal. Supplement·T SandströmG Viegi
Jul 12, 2003·Bioinformatics·Jung Kyoon ChoiOok Joon Yoo
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gary N LandisJohn Tower
Jun 25, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robert N ButlerNorman Wolf
Nov 13, 2004·Current Topics in Developmental Biology·Andrzej Bartke, Holly Brown-Borg
Dec 1, 2004·Aging Cell·Daniel Amador-NoguezGretchen Darlington
Jan 25, 2005·Mechanisms of Ageing and Development·David Gems, Joshua J McElwee
Feb 5, 2005·The EMBO Journal·Joanna M PrasherLaura J Niedernhofer
Jun 1, 2005·Biochemical and Biophysical Research Communications·Daniel Amador-NoguezGretchen Darlington
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Derrick J RossiIrving L Weissman
Aug 4, 2005·Bioinformatics·Claire L Wilson, Crispin J Miller
Jan 20, 2006·Genome Biology·Kristian WennmalmOla Larsson
Nov 10, 2006·Mechanisms of Ageing and Development·Chunxiao FuEun-Soo Han
Feb 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Monica B PaganoChristine T N Pham
Apr 27, 2007·Annals of the New York Academy of Sciences·Leonard Hayflick
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Carla B GreenJoseph C Besharse
May 25, 2007·Aging Cell·Daniel Amador-NoguezGretchen Darlington
Jun 6, 2007·The Journal of Experimental Medicine·Qian YuanAndrew D Luster
Jul 7, 2007·Genome Biology·Joshua J McElweeDavid Gems
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ahmed M Elsharkawy, Derek A Mann
Aug 30, 2007·Physiological Genomics·Vikas MisraClarke G Tankersley
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dayong WuSimin Nikbin Meydani

❮ Previous
Next ❯


Jul 23, 2014·Oxidative Medicine and Cellular Longevity·Kazushige OtaKazuhiko Igarashi
Sep 30, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Russell Hodgson, Chris Christophi
Dec 15, 2015·Annals of the American Thoracic Society·Mauricio RojasOliver Eickelberg
Nov 26, 2015·Brain Research·Daniela Cornacchia, Lorenz Studer
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Jan 23, 2015·Cell Death & Disease·C H WilsonS Kumar
Nov 24, 2017·Npj Aging and Mechanisms of Disease·Irene AlfarasRafael de Cabo
May 1, 2018·ELife·Christine MüllerCornelis F Calkhoven
Mar 2, 2018·Biogerontology·Stephen Frenk, Jonathan Houseley
Jan 30, 2019·Rejuvenation Research·Xue-Lian SunBi-Rong Dong
Nov 7, 2015·BMC Genomics·Ryan R WhiteJan Vijg
Jul 28, 2020·Npj Aging and Mechanisms of Disease·Michel BernierRafael de Cabo
Feb 13, 2021·Npj Aging and Mechanisms of Disease·Michel BernierRafael de Cabo
Mar 4, 2020·Mechanisms of Ageing and Development·Bushra AminRenã A S Robinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2021 Meta ULC. All rights reserved