Meta-Analysis of Genes in Commercially Available Nutrigenomic Tests Denotes Lack of Association with Dietary Intake and Nutrient-Related Pathologies

Omics : a Journal of Integrative Biology
Cristiana PavlidisGeorge P Patrinos

Abstract

Nutrigenomics is an emerging discipline that aims to investigate how individual genetic composition correlates with dietary intake, as well as how nutrition influences gene expression. Herein, the fundamental question relates to the value of nutrigenomics testing on the basis of the currently available scientific evidence. A thorough literature search has been conducted in PubMed scientific literature database for nutrigenomics research studies on 38 genes included in nutrigenomics tests provided by various private genetic testing laboratories. Data were subsequently meta-analyzed to identify possible associations between the genes of interest and dietary intake and/or nutrient-related pathologies. Data analysis occurred according to four different models due to data sparsity and inconsistency. Data from 524,592 individuals (361,153 cases and 163,439 controls) in a total of 1,170 entries were obtained. Conflicting findings indicated that there was a great incompatibility regarding the associations (or their absence) identified. No specific--and statistically significant-association was identified for any of the 38 genes of interest. In those cases, where a weak association was demonstrated, evidence was based on a limited numbe...Continue Reading

References

Oct 14, 2003·Plant Physiology·Matthew D RasmussenErnest F Retzel
May 7, 2011·Briefings in Bioinformatics·John R ThompsonCosetta Minelli
Feb 15, 2012·Advances in Nutrition·Botao Liu, Shu-Bing Qian
Jul 10, 2013·Human Genomics·George P PatrinosDavid N Cooper
Dec 3, 2013·Genes & Nutrition·T HurlimannB Godard
Jan 21, 2014·Journal of the Academy of Nutrition and Dietetics·Kathryn M Camp, Elaine Trujillo
Jan 24, 2014·PloS One·Jingzhou WangAhmed El-Sohemy
Jun 10, 2014·Omics : a Journal of Integrative Biology·Elizabeth MontagueEugene Kolker

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Citations

Dec 1, 2015·Omics : a Journal of Integrative Biology·Lynnette R Ferguson
Dec 10, 2015·Journal of Neural Transmission·Vural ÖzdemirSanjeeva Srivastava
Sep 28, 2016·Public Health Genomics·Athanassios VozikisGeorge P Patrinos
Nov 28, 2017·Omics : a Journal of Integrative Biology·Angeliki BalasopoulouGeorge P Patrinos
Aug 3, 2017·Omics : a Journal of Integrative Biology·Stefanie Malan-MullerSian M J Hemmings
Oct 21, 2015·Omics : a Journal of Integrative Biology·Vural Özdemir
Jan 30, 2019·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Erin TuttySylvia A Metcalfe
Feb 9, 2019·Cognitive Behaviour Therapy·Simon B GoldbergTracy L Simpson
Jul 25, 2019·Food & Function·María-Carmen López de Las HazasAlberto Dávalos
Apr 25, 2020·Personalized Medicine·Maria KorominaGeorge P Patrinos
Dec 3, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ying CuiLei Wang
Jan 30, 2021·The British Journal of Nutrition·Nathan V MatusheskiSzabolcs Péter
Nov 30, 2019·Public Health Genomics·Suchetana DeKirsi Vähäkangas

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