Meta-analysis of genetic association studies on bipolar disorder.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Fayaz SeifuddinPeter P Zandi

Abstract

Numerous candidate gene association studies of bipolar disorder (BP) have been carried out, but the results have been inconsistent. Individual studies are typically underpowered to detect associations with genes of small effect sizes. We conducted a meta-analysis of published candidate gene studies to evaluate the cumulative evidence. We systematically searched for all published candidate gene association studies of BP. We then carried out a random-effects meta-analysis on all polymorphisms that were reported on by three or more case-control studies. The results from meta-analyses of these genes were compared with the findings from a recent mega-analysis of eleven genome-wide association studies (GWAS) in BP performed by the Psychiatric GWAS Consortium (PGC). A total of 487 articles were included in our review. Among these, 33 polymorphisms in 18 genes were reported on by three or more case-control studies and included in the random-effects meta-analysis. Polymorphisms in BDNF, DRD4, DAOA, and TPH1, were found to be nominally significant with a P-value < 0.05. However, none of the findings were significant after correction for multiple testing. Moreover, none of these polymorphisms were nominally significant in the PGC-BP GWAS....Continue Reading

References

Feb 1, 1992·The American Journal of Psychiatry·M M NöthenP Propping
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 14, 1995·American Journal of Medical Genetics·N CraddockM J Owen
Jun 19, 1995·American Journal of Medical Genetics·A ParsianR D Todd
Feb 1, 1995·Journal of Medical Genetics·I Pérez de CastroJ Fernández-Piqueras
Sep 15, 1994·American Journal of Medical Genetics·L C LimM Gill
Nov 1, 1994·Journal of Medical Genetics·I Pérez de CastroC Llinares
Apr 1, 1993·Journal of Medical Genetics·S ShaikhM Gill
Jul 26, 1996·American Journal of Medical Genetics·T SasakiJ L Kennedy
Sep 9, 1996·Journal of Affective Disorders·H MankiM Asai
Jan 1, 1997·The American Journal of Psychiatry·B GutiérrezL Fañanás
Mar 15, 1997·Biological Psychiatry·F BellivierJ M Launay
Apr 1, 1997·Biological Psychiatry·H Y ZhangK Ohara
Oct 28, 1997·Human Genetics·B GutiérrezL Fañanás
Oct 28, 1997·American Journal of Medical Genetics·T MuramatsuM Asai
Oct 28, 1997·American Journal of Medical Genetics·T ArinamiM Toru
Jan 22, 1998·Archives of General Psychiatry·F BellivierA Malafosse
Mar 26, 1998·American Journal of Medical Genetics·M R HoeheM A Crocq
May 13, 1998·Molecular Psychiatry·A SerrettiE Smeraldi

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Citations

May 15, 2013·Lancet·Nick Craddock, Pamela Sklar
Jan 23, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jinjing TanLian Gu
Sep 11, 2013·Molecular Psychiatry·M PiroozniaP P Zandi
Oct 8, 2014·Journal of Psychiatric Research·Justine M GattPeter R Schofield
Feb 24, 2016·Schizophrenia Research·Diego A ForeroJurgen Del-Favero
Feb 20, 2013·Expert Opinion on Therapeutic Targets·Murtada AlsaifSabine Bahn
Mar 27, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Mohammad GhadiriEhsan Moazen Zadeh
May 28, 2013·Expert Opinion on Drug Discovery·Nicolas HoertelPhilip Gorwood
Jun 26, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jinjing TanLian Gu
Apr 25, 2015·International Journal of Bipolar Disorders·Jessica N HoltzmanGustavo H Vázquez
Jun 13, 2015·Journal of Affective Disorders·Biju ViswanathSanjeev Jain
Jun 10, 2015·Journal of Affective Disorders·Kevin P KennedyBonnie Klimes-Dougan
Jul 18, 2014·European Archives of Psychiatry and Clinical Neuroscience·Thomas Nickl-JockschatTilo Kircher
Apr 2, 2015·Journal of Affective Disorders·Shanker SwaminathanJohn I Nurnberger
Dec 3, 2014·Journal of Affective Disorders·Kaya K JacobsenKetil J Oedegaard
Jun 5, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christian G BouwkampSteven A Kushner
Feb 9, 2017·Psychiatric Genetics·Sally Isabel SharpAndrew McQuillin
Apr 26, 2014·Experimental Biology and Medicine·Caterina IofridaSilvia Pellegrini
Jun 27, 2018·Molecular Psychiatry·Tanya HorwitzChunyu Liu
Oct 11, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·S BarralY Stern
Dec 13, 2018·Frontiers in Psychiatry·Artur ReginiaJerzy Samochowiec
Jul 5, 2019·Expert Review of Neurotherapeutics·Alfredo B Cuellar-BarbozaSusan L McElroy
Apr 25, 2020·Translational Psychiatry·Alexander W CharneyJonathan Xu
Sep 4, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rodrigo Machado-VieiraCarlos A Zarate

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