Aug 2, 2011

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

Nature Genetics
Dara G TorgersonDan L Nicolae

Abstract

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.

  • References25
  • Citations406
  • References25
  • Citations406

Citations

Mentioned in this Paper

TSLP protein, human
Genome-Wide Association Study
Meta-Analysis (Publications)
PYHIN1 gene
European Continental Ancestry Group
African American
Asthma
PYHIN1
Latinas
Locus

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