Meta-analysis of ocular axial length in newborns and infants up to 3 years of age.

Survey of Ophthalmology
Annabel L W GrootDyonne T Hartong

Abstract

In pediatric ophthalmology it is often necessary to obtain axial length in young children. For children older than 3 years, noncontact biometry can be used. For younger children this is usually not an option, and the clinician needs to rely on other imaging modalities. Depicted data curves in textbooks elaborate on few studies and limited number of subjects. The existing literature regarding normal axial length for preterm infants and term newborns is summarized and critically appraised for number of subjects, relevance, measurement method and error, gender and retinopathy of prematurity. We obtained axial length measurements for a total number of 6,575 eyes in 27 papers published from 1964 to 2018 (9 papers with 2,272 eyes for preterm children, 24 papers with 4,303 eyes for term children). Initially, axial length increases rapidly: from a mean 5.1-16.2 mm in week 12 to week 37 gestational age. From 38 weeks, growth rate decreases from 16.2 mm to a mean of 21.8 mm at 3 years old. Male infants have a larger average axial length than females at birth; the difference is 0.24 mm (95%CI: 0.15-0.33, P < 0.001). We present a useful growth curve and formula that may serve as a reference for diagnosing abnormal growth.

References

Jan 1, 1979·Acta Ophthalmologica·S Blomdahl
Nov 1, 1989·Archives of Ophthalmology·A H WeissJ Longbottom
Nov 1, 1989·Archives of Ophthalmology·A H WeissJ Longbottom
Jan 1, 1968·Acta Ophthalmologica·N EhlersH Andersen
Jan 1, 1984·Journal - American Intra-Ocular Implant Society·H J Shammas
Apr 1, 1982·Archives of Ophthalmology·R Sampaolesi, R Caruso
May 1, 1995·Ophthalmology·S J IsenbergA J Ziffer
Feb 1, 1994·Ophthalmology·J R StaffordJ C Merriam
Oct 1, 1996·The British Journal of Ophthalmology·H C Fledelius, A C Christensen
Aug 1, 1997·Acta Ophthalmologica Scandinavica·A HellströmK Strömland
Feb 1, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G KieferF Grehn
Feb 26, 2003·Investigative Ophthalmology & Visual Science·Anne CookDavid Clark
Nov 17, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Andrew CarkeetDonald T H Tan
Sep 28, 2007·Investigative Ophthalmology & Visual Science·Rupal H Trivedi, M Edward Wilson
Dec 7, 2007·Investigative Ophthalmology & Visual Science·Ruth Axer-SiegelMoshe Snir
Jul 20, 2016·Journal of Pediatric Ophthalmology and Strabismus·Patrick M AzcarateKara M Cavuoto
Aug 12, 2016·Turkish Journal of Medical Sciences·Özdemir ÖzdemirDamla Ergintürk Acar
Nov 23, 2017·Journal of Ophthalmology·Yi ZhaWangqiang Feng
Dec 30, 2017·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Jos J RozemaRuth Axer-Siegel
May 29, 2018·Journal of Pediatric Ophthalmology and Strabismus·Usha K RainaVarun Saini
Oct 20, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Donald O MuttiWendy K Lin
Jan 15, 2019·Taiwan Journal of Ophthalmology·Michael J ShapiroSayena Jabbehdari
Jan 15, 2019·Investigative Ophthalmology & Visual Science·Dimitrios KardarasEvangelia E Tsironi

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