Meta-analysis of perioperative antibiotics in patients undergoing laparoscopic cholecystectomy

The British Journal of Surgery
S PasqualiWest Midlands Research Collaborative

Abstract

The effectiveness of perioperative antibiotics in reducing surgical-site infection (SSI) and overall nosocomial infections in patients undergoing laparoscopic cholecystectomy for biliary colic and low- and moderate-risk cholecystitis (Tokyo classification) is unclear. A systematic review and meta-analysis was performed to assess this. Searches were conducted of the MEDLINE, Embase and Cochrane databases. Only randomized clinical trials (RCTs) were included. The analysis was performed using the random-effects method, and the risk ratio (RR) with 95 per cent c.i. was employed. Nineteen RCTs, published between 1997 and 2015, with a total of 5259 participants, of whom 2709 (51·5 per cent) were treated with antibiotics, were included. SSI and overall nosocomial infections were detected in 2·4 and 4·2 per cent respectively of patients given perioperative antibiotics, and in 3·2 and 7·2 per cent of those who received no antibiotics. Antibiotics did not significantly reduce the risk of SSI (RR 0·81, 95 per cent c.i. 0·58 to 1·13; P = 0·21) or overall nosocomial infections (RR 0·64, 0·36 to 1·14; P = 0·13). There was no significant between-study heterogeneity for SSI, but significant between-study heterogeneity in the eight studies that...Continue Reading

References

Feb 1, 1990·Archives of Surgery·J E ThompsonH A Pitt
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 26, 2005·The Journal of Infection·Zeina A KanafaniAla I Sharara
Sep 10, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Abhishek ChoudharyPraveen K Roy
Feb 25, 2009·Alimentary Pharmacology & Therapeutics·H ZhouZ Hu
Oct 2, 2009·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Mehmet UludagBulent Citgez
Nov 11, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Patrik LundströmGunnar Persson
Feb 26, 2010·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Arjan Berkeljon, Scott A Baldwin
Dec 15, 2010·The Cochrane Database of Systematic Reviews·Alvaro SanabriaGabriel Gomez
Mar 30, 2011·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Rui-Cheng YanJan Riley
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Jan 24, 2013·Journal of Hepato-biliary-pancreatic Sciences·Masamichi YokoeUNKNOWN Tokyo Guidelines Revision Committee
May 2, 2013·The Cochrane Database of Systematic Reviews·Peter DaveyMark Wilcox
Apr 24, 2014·BMJ : British Medical Journal·Kurinchi S Gurusamy, Brian R Davidson
Jul 6, 2014·Annals of the Royal College of Surgeons of England·H E GrahamD Nehra
Jul 10, 2014·JAMA : the Journal of the American Medical Association·Jean Marc RegimbeauUNKNOWN FRENCH Study Group
Oct 2, 2014·The Journal of Clinical Investigation·Martin J Blaser
Jul 1, 2010·Medical Journal, Armed Forces India·A Gaur, A K Pujahari

❮ Previous
Next ❯

Citations

Feb 23, 2019·Surgical Infections·Aafke H van DijkMarja A Boermeester
Jan 11, 2017·Annals of the Royal College of Surgeons of England·Caw MacanoR S Vohra
Apr 27, 2017·World Journal of Surgery·Ravinder S VohraUNKNOWN CholeS Study Group and West Midlands Research Collaborative
Mar 21, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Juan Camilo Gomez-OspinaHerney Andrés García-Perdomo
Jun 22, 2017·World Journal of Surgery·Gona JaafarGabriel Sandblom
Feb 29, 2020·Hernia : the Journal of Hernias and Abdominal Wall Surgery·D RussellR Lim
Oct 18, 2018·Surgical Endoscopy·Davide La ReginaAntonjacopo Ferrario di Tor Vajana
Sep 15, 2018·Annals of Hepato-biliary-pancreatic Surgery·Sang Hoon KimHong Pil Hwang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.