Meta-Analysis of Personality Traits in Alzheimer's Disease: A Comparison with Healthy Subjects

Journal of Alzheimer's Disease : JAD
Alfonsina D'IorioGabriella Santangelo

Abstract

The role of specific personality traits as factor risks of Alzheimer's disease (AD) has been consistently found, whereas personality traits specifically related to AD (after the diagnosis) have not been outlined yet. A meta-analysis of published studies was performed to determine whether AD patients have a distinctive personality trait profile compared to healthy subjects (HC), similar to or different from a premorbid personality profile consistently reported in previous studies. A systematic literature search was performed using PsycInfo (PROQUEST), PubMed, and Scopus. The meta-analysis pooled results from primary studies using Hedges' g unbiased approach. The meta-analysis included 10 primary studies and revealed that, when the personality was evaluated by informant-rated measures, AD patients had significantly higher levels of Neuroticism, lower levels of Openness, Agreeableness, Conscientiousness, and Extraversion than HCs. When the personality was evaluated by self-rated measures, the results obtained from informants were confirmed for Neuroticism, Openness, and Extraversion but not for Agreeableness and Conscientiousness where AD patients and HCs achieved similar scores. The meta-analysis revealed that high Neuroticism an...Continue Reading

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Citations

Dec 14, 2019·The Journal of General Psychology·Joana Henriques-Calado, Maria Eugénia Duarte-Silva
Oct 28, 2019·Aging Clinical and Experimental Research·Barbara ColomboRosa Angela Fabio
Apr 29, 2020·Brain Structure & Function·Hamid R SohrabiRalph N Martins
Aug 10, 2019·Frontiers in Aging Neuroscience·José Manuel Santacruz EscuderoHernando Santamaría-García
Nov 20, 2018·Scientific Reports·Jens GemptFlorian Ringel
Jan 12, 2019·Journal of the American Medical Directors Association·Maheen IslamAntonio Terracciano
Aug 6, 2021·Neuroscience Insights·Vladan BajicGeorge Perry

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