PMID: 9167518Jun 1, 1997Paper

Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia

The American Journal of Psychiatry
R J BaldessariniF M Benes

Abstract

To evaluate the hypothesis that patients with schizophrenia who have been treated with neuroleptics have a high rate of Alzheimer's disease-like neuropathology. Neuropathological studies indicating the presence or absence of Alzheimer's disease-like neuropathology in the postmortem brains of patients with schizophrenia, normal comparison subjects, and comparison subjects who had affective disorder were evaluated with Mantel-Haenszel chi-square and odds ratio analyses. Ten studies with relevant data were reviewed; none of eight with comparisons indicated that Alzheimer's disease-like neuropathology was more likely to be found in the brains of patients with schizophrenia than in the brains of comparison subjects. Suggestions that cerebral plaques and neurofibrillary tangles are more common in schizophrenia in association with neuroleptic treatment were not supported.

Citations

Nov 18, 2009·Molecular Psychiatry·J R BustilloJ Lauriello
Mar 21, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ho Seok LeeSe Hwan Hwang
Dec 14, 2006·Journal of Neural Transmission·A SchmittH Kretzschmar
Dec 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juan R BustilloJohn Lauriello
Jul 21, 2004·Molecular Psychiatry·P J Harrison, D R Weinberger
Jun 6, 2003·Applied Neuropsychology·Konstantine K ZakzanisTaline Sethian
Jun 10, 2000·Histopathology·M K Heatley
Jul 16, 2005·Aging & Mental Health·S KarimA Burns

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