Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

Inflammatory Bowel Diseases
Junji UmenoMichiaki Kubo


Both ulcerative colitis (UC) and Crohn's disease (CD) have a complex etiology involving multiple genetic and environmental factors. Many genome-wide association studies (GWAS) and subsequent replication studies revealed that both diseases share some of the susceptibility loci; however, common genetic factors for both diseases are not fully elucidated. This study is aimed to identify the common genetic factors for CD and UC by a meta-analysis of published studies. We first reviewed the 10 GWAS for CD to select candidate single nucleotide polymorphisms (SNPs). Next, we performed a PubMed literature search up to June 30, 2010 and carried out a systemic review of published studies that examined the association of CD susceptibility loci in UC patients. Meta-analysis was carried out using the inverse variance-weighted method or the DerSimonian-Laird method after estimating the heterogeneity among the studies. The data for highly linked SNPs were combined. Finally, we performed a meta-analysis of 43 published studies in 45 SNPs located at 33 loci by using a total of 4852 to 31,125 subjects. We confirmed the association of 17 reported common susceptibility loci. Moreover, we found associations at eight additional loci: GCKR, ATG16L1, C...Continue Reading


Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Mar 23, 2002·Gastroenterology·Andrew P CuthbertChristopher G Mathew
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Aug 1, 1963·Annals of Internal Medicine·J B KIRSNER, J A SPENCER
Mar 30, 2004·The American Journal of Gastroenterology·Nele EstersPaul Rutgeerts
Dec 2, 2004·The American Journal of Gastroenterology·Michael EconomouJohn P A Ioannidis
Jan 8, 2005·World Journal of Gastroenterology : WJG·Carsten BüningHerbert Lochs
Oct 14, 2005·Human Molecular Genetics·Keiko YamazakiYusuke Nakamura
Jun 15, 2006·World Journal of Gastroenterology : WJG·Leena HalmeKimmo Kontula
Aug 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L E OostenbrugJ H Kleibeuker
Apr 25, 2007·World Journal of Gastroenterology : WJG·S CucchiaraV Annese
Apr 27, 2007·Nature Genetics·Valgerdur SteinthorsdottirKari Stefansson
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
May 18, 2007·Inflammatory Bowel Diseases·J R Fraser CummingsDerek P Jewell
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Aug 9, 2007·PloS One·Andre FrankeStefan Schreiber
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·John V RaelsonStefan Schreiber
Sep 19, 2007·World Journal of Gastroenterology : WJG·Michael EconomouEpameinondas V Tsianos
Jan 15, 2008·Nature Genetics·Cristen J WillerGonçalo R Abecasis
Apr 3, 2008·Inflammatory Bowel Diseases·Ana MárquezAlfonso Martínez
May 24, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P L LakatosUNKNOWN Hungarian IBD Study Group
Jul 26, 2008·Nature Nanotechnology
Oct 1, 2008·Gut·R K WeersmaUNKNOWN Dutch Initiative on Crohn and Colitis (ICC)

❮ Previous
Next ❯


Mar 20, 2012·International Journal of Colorectal Disease·Chaolan LvFachao Zhi
Dec 24, 2011·Journal of Molecular Neuroscience : MN·Markos PoulopoulosRoy N Alcalay
Jul 28, 2013·Human Molecular Genetics·Kyle B FraserAndrew B West
Feb 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark S MoehleAndrew B West
Apr 8, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mahmoud MosliMajid Almadi
Mar 25, 2014·Journal of Neuroinflammation·Isabella RussoElisa Greggio
Mar 29, 2013·Rheumatology International·Anthoula ChatzikyriakidouAlexandros A Drosos
Jun 5, 2013·Neurochemical Research·Hardy J Rideout, Leonidas Stefanis
Nov 30, 2014·Clinics in Dermatology·Monica E D SauerMarcelo T Mira
Apr 1, 2014·Human Molecular Genetics·Jason SchapanskyMatthew J LaVoie
Mar 27, 2012·Journal of Crohn's & Colitis·Cinzia CiccacciPaola Borgiani
Oct 18, 2014·Expert Opinion on Therapeutic Targets·Clarence HaleMurielle M Véniant
Mar 7, 2012·Expert Review of Clinical Immunology·Puja Vora, Dermot P B McGovern
Nov 5, 2013·Autoimmunity Reviews·Elena GianchecchiAlessandra Fierabracci
Jan 12, 2016·Inflammatory Bowel Diseases·Timna NaftaliUri Gophna
Jan 17, 2016·Clinics in Dermatology·Monica E D SauerMarcelo T Mira
Oct 21, 2015·Frontiers in Cell and Developmental Biology·Elizabeth A Novak, Kevin P Mollen
Dec 17, 2014·Clinics and Research in Hepatology and Gastroenterology·Min LiuWeiguo Dong
Sep 20, 2012·Biochemical Society Transactions·Nicolas Dzamko, Glenda M Halliday
Dec 3, 2014·Neuroscience·N DzamkoG M Halliday
Dec 21, 2011·Cellular Signalling·Colin D WhiteDavid B Sacks
May 28, 2013·Biochimica Et Biophysica Acta·Wiljan J A J Hendriks, Rafael Pulido
Jun 19, 2013·Bioorganic & Medicinal Chemistry Letters·Thomas TroxlerDerya R Shimshek
Apr 22, 2015·Inflammatory Bowel Diseases·Christopher J MoranScott B Snapper
Dec 17, 2014·Trends in Genetics : TIG·Fowzan S Alkuraya
Mar 4, 2015·Gut·Sung Noh HongUNKNOWN IBD Study Group of the Korean Association for the Study of Intestinal Diseases (KASID)
Oct 25, 2017·Journal of Neural Transmission·Caroline BaufeldOleg Butovsky
May 24, 2018·The EMBO Journal·Anetta HärtlovaMaximiliano G Gutierrez
Oct 15, 2019·Journal of Parkinson's Disease·Tomasz Brudek
Nov 20, 2016·Journal of Neuroinflammation·Rakel López de MaturanaRosario Sánchez-Pernaute
Mar 27, 2020·Frontiers in Neuroscience·Diba Ahmadi Rastegar, Nicolas Dzamko

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.