Meta-analysis of randomized controlled trials for the efficacy and safety of anti-interleukin-13 therapy with lebrikizumab in patients with uncontrolled asthma

Allergy and Asthma Proceedings
Ying LiuYingnan Cao

Abstract

Several studies have evaluated the efficacy and safety of lebrikizumab treatment with uncontrolled asthma. However, most of these studies were small and conclusions were inconsistent. Furthermore, whether serum periostin can act as a good predictor of the response to lebrikizumab treatment is still not certain. We conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy and safety of lebrikizumab treatment with uncontrolled asthma. Trials were searched in PubMed, Embase, Web of Science and Cochrane. Outcome measures were the rate of asthma exacerbations, relative changes in the forced expiratory volume in the first second of expiration (FEV1) of predicted value (%) and incidence of adverse events. Five trials were finally included. Compared with placebo lebrikizumab treatment significantly decreased the rate of exacerbations(risk ratio [RR] 0.66 [95% confidence interval {CI}, 0.54-0.80]; p < 0.0001; n = 2039) and increased FEV1% of predicted value (weighted mean difference [WMD] 5.46 [95% CI, 2.48-8.43]; p < 0.0003; n = 351). Patients with high levels of serum periostin had greater exacerbation rate reductions (RR 0.59 [95%CI, 0.50-0.70]; p < 0.00001; n = 1157) and FEV1 of predict...Continue Reading

Citations

Dec 12, 2018·American Journal of Respiratory and Critical Care Medicine·Mary Clare McGregorMario Castro
Jan 17, 2019·Current Opinion in Allergy and Clinical Immunology·Elise M SlobMariëlle W Pijnenburg
Aug 23, 2019·The Journal of Dermatological Treatment·Kevin K WuApril W Armstrong
Jul 7, 2020·Frontiers in Immunology·Grzegorz KardasMichał Panek
Aug 16, 2019·Expert Review of Respiratory Medicine·Federica PorcaroGiovanni Battista Pajno
Apr 18, 2021·Immunology and Allergy Clinics of North America·Sultan Albuhairi, Rima Rachid

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