Meta-analysis of randomized trials of effect of milrinone on mortality in cardiac surgery: an update

Journal of Cardiothoracic and Vascular Anesthesia
David T MajureGiovanni Landoni

Abstract

The long-term use of milrinone is associated with increased mortality in chronic heart failure. A recent meta-analysis suggested that it might increase mortality in patients undergoing cardiac surgery. The authors conducted an updated meta-analysis of randomized trials in patients undergoing cardiac surgery to determine if milrinone impacted survival. A meta-analysis. Hospitals. One thousand thirty-seven patients from 20 randomized trials. None. Biomed, Central, PubMed, EMBASE, the Cochrane central register of clinical trials, and conference proceedings were searched for randomized trials that compared milrinone versus placebo or any other control in adult and pediatric patients undergoing cardiac surgery. Authors of trials that did not include mortality data were contacted. Only trials for which mortality data were available were included. Overall analysis showed no difference in mortality between patients receiving milrinone versus control (12/554 [2.2%] in the milrinone group v 10/483 [2.1%] in the control arm; relative risk [RR] = 1.15; 95% confidence interval [CI], 0.55-2.43; p = 0.7) or in analysis restricted to adults (11/364 [3%] in the milrinone group v 9/371 [2.4%] in the control arm; RR = 1.17; 95% CI, 0.54-2.53; p =...Continue Reading

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Citations

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Jun 21, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Abhi MishraAnand Kumar Mishra
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Dec 17, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Alessandro BellettiSilvia Ajello

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