Meta-analysis of sex differences in gene expression in schizophrenia

BMC Systems Biology
Wenyi QinHui Lu

Abstract

Schizophrenia is a severe psychiatric disorder which influences around 1% of the worldwide population. Differences between male and female patients with schizophrenia have been noted. There is an earlier age of onset in males compared with females with this diagnosis, and in addition, there are differences in symptom profiles between the sexes. The underlying molecular mechanism of sex difference remains unclear. Here we present a comprehensive analysis to reveal the sex differences in gene expression in schizophrenia with stringent statistics criteria. We compiled a data set consisting of 89 male controls, 90 male schizophrenia patients, 35 female controls and 32 female schizophrenia patients from six independent studies of the prefrontal cortex (PFC) in postmortem brain. When we tested for a sex by diagnosis interaction on gene expression, 23 genes were up-regulated and 23 genes were down-regulated in the male group (q-value < 0.05), several genes are related to energy metabolism, while 4 genes are located on sex chromosome. No genes were statistically significant in the female group when multiple testing correction were conducted (q-value <0.05), most likely due to the small sample size. Our protocol and results from the mal...Continue Reading

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Citations

Aug 31, 2016·Psychiatry Research·Awatef EsshiliBesma Bel Hadj Jrad
Oct 30, 2016·Frontiers in Genetics·Benjamin T MayneClaire T Roberts
Nov 2, 2019·Genes, Brain, and Behavior·Nicole Leitner, Yehuda Ben-Shahar
Jun 20, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marie-Julie AllardGuillaume Sebire
Jun 21, 2019·Applied Psychophysiology and Biofeedback·Maria PallayovaDiana Tokarova
Jun 8, 2017·BMC Medical Genomics·Matthew B CarsonHui Lu
May 12, 2021·Schizophrenia Bulletin·Jing LuAi-Min Bao
Jun 23, 2021·Biological Psychiatry·Gabriel E HoffmanPanos Roussos

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Methods Mentioned

BETA
PCA
PCR

Software Mentioned

DAVID webserver
EASE ( Expression Analysis Systematic Explorer )
sva
R
qvalue
DAVID ( Database for Annotation , Visualization and Integrated...
ComBat

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