Meta-analysis of SUMO1.

BMC Research Notes
Brian J Wilson

Abstract

An abundantly growing body of literature implicates conjugation of SUMO in the regulation of many proteins and processes, yet the regulation of SUMO pathways is poorly understood. To gain insight into the players in the SUMO1 pathway I have performed an in-silico co-expression meta-analysis of SUMO1, comparing many different multi-microarray studies of various normal and human tumour tissues, from the Oncomine database. This serves as a data-driven predictor of pathway partners of SUMO1. While the data obtained need to be confirmed by future independent experiments and can currently only be considered a hypothesis, results implicate defender against cell death (DAD1) and the anti-apoptotic DEK oncogene as new pathway partners of SUMO1.

References

Oct 7, 2004·Biochemical and Biophysical Research Communications·Seong-Hui BaeKyu-Won Kim
Jul 1, 2005·The Journal of Biological Chemistry·Joanne ClearyDavid M Markovitz
Aug 9, 2006·Molecular and Cellular Biology·Trisha M Wise-DraperSusanne I Wells
Mar 14, 2007·Molecular and Cellular Biology·Zhiyong DengGuangchao Sui

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Citations

Nov 15, 2008·Journal of Carcinogenesis·Brian J Wilson
Dec 4, 2012·Oncology Letters·Lokman Varisli

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Software Mentioned

Oncomine

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