Meta-analysis of the accuracy of p16 or p16/Ki-67 immunocytochemistry versus HPV testing for the detection of CIN2+/CIN3+ in triage of women with minor abnormal cytology

Cancer Cytopathology
Eliana PeetersMarc Arbyn

Abstract

Women with atypical squamous cells of undetermined significance (ASC-US) can be triaged accurately with a high-risk human papillomavirus (hrHPV) test to identify those who need a referral. However, the triage of low-grade squamous intraepithelial lesion (LSIL) with hrHPV testing has very low specificity. Overexpression of p16, with or without Ki-67, indicates neoplastic transformation of human papillomavirus-infected cervical cells and may more accurately predict underlying cervical intraepithelial neoplasia of grade 3 or worse (CIN3+). A literature search was conducted in 3 bibliographic databases. Studies were selected if they included women with ASC-US or LSIL who were triaged with dual staining (p16/Ki-67) and/or p16 staining and, if available, with a comparator hrHPV test to detect cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) or CIN3+. Thirty-eight studies were eligible. The sensitivity of p16 staining for CIN3+ was significantly lower than that of hrHPV DNA testing (ratio for ASC-US, 0.87; 95% confidence interval [CI], 0.78-0.97; ratio for LSIL, 0.86; 95% CI, 0.80-0.93). In contrast, the specificity of p16 staining was substantially higher with relative specificities of 1.60 (95% CI, 1.35-1.88) and 2.29 ...Continue Reading

References

Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·C J Sherr
Dec 8, 2004·Acta Cytologica·Marcus J TrunkMagnus von Knebel Doeberitz
Mar 16, 2006·Gynecologic Oncology·Luis Otavio SarianLiliana Aparecida Lucci De Angelo Andrade
May 4, 2007·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·C Meg McLachlinUNKNOWN Cervical Screening Guidelines Development Committee of the Ontario Cervical Screening Program and the Gynecology Cancer Dise
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kate Cuschieri, Nicolas Wentzensen
Oct 30, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne SzarewskiJack Cuzick
Dec 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Eun-Kyoung Yim, Jong-Sup Park
Feb 16, 2010·American Journal of Clinical Pathology·Christine BergeronUNKNOWN European CINtec Histology Study Group
Feb 24, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ArbynL von Karsa
Jun 17, 2010·American Journal of Clinical Pathology·Karin J DentonUNKNOWN European CINtec Cytology Study Group
Jul 28, 2010·The American Journal of Surgical Pathology·Mary T GalganoMark H Stoler
Sep 21, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Richard W Burry
Jan 22, 2011·Diagnostic Cytopathology·Francesc AlamedaSergi Serrano
Feb 19, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Maria NasioutzikiPetros Karakitsos
Jun 29, 2011·Diagnostic Cytopathology·Neil EdgertonMomin T Siddiqui
May 23, 2012·International Journal of Cancer. Journal International Du Cancer·Marc ArbynJoseph Monsonego
Jun 8, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicolas WentzensenMark Schiffman
Nov 8, 2012·Virology Journal·André L P AbreuMarcia E L Consolaro
Jun 14, 2013·Journal of Lower Genital Tract Disease·Jeffrey L KilleenMark Hiraoka
Nov 7, 2013·Oncotarget·Karl MungerMargaret E McLaughlin-Drubin
Nov 23, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·D Vrdoljak-MozetičM Bubonja-Šonje

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Citations

Aug 2, 2019·Expert Review of Molecular Diagnostics·Kathryn A KundrodRebecca Richards-Kortum
Apr 7, 2020·International Journal of Cancer. Journal International Du Cancer·Remila RezhakeMarc Arbyn
Aug 12, 2020·International Journal of Cancer. Journal International Du Cancer·Mariam El-ZeinUNKNOWN STAIN-IT Study Group
Mar 15, 2020·International Journal of Cancer. Journal International Du Cancer·Jack CuzickUNKNOWN New Technologies for Cervical Cancer Screening Working Group
Oct 13, 2020·Expert Review of Molecular Diagnostics·Mariano A MolinaKarolina M Andralojc
Feb 2, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Simon LeesonChristine Bergeron
Jul 11, 2021·Japanese Journal of Clinical Oncology·Chisato Hamashima
Dec 19, 2021·International Journal of Cancer. Journal International Du Cancer·Erika Hurtado-SalgadoEduardo Lazcano-Ponce

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