Meta-analysis of the differentially expressed microRNA profiles in nasopharyngeal carcinoma

Oncotarget
Junwen LuanXiaoqun Xu

Abstract

MicroRNAs(miRNAs), as non-coding molecules, were proved to be correlated with gene expression in naspharyngeal carcinoma (NPC) development. In this research, a comprehensive meta-analysis of eight independent miRNA expression studies in NPC was preformed by using robust rank aggregation method (RRA), which contained a total of 775 tumor and 227 non-cancerous samples. There were 7 significant dysregulated miRNAs identified including three increased (miR-483-5p, miR-29c-3p and miR-205-5p) and four decreased (miR-29b-3p, let-7d-5p, miR-100- 5p and let-7g-5p) miRNAs. Subsequently, the miRNA target prediction and pathway enrichment analysis were carried out to find out the biological and functional relevant genes involved in the meta-signature miRNA regulation. Finally, several signaling and cancer pathogenesis pathways were suggested to be more frequently associated with the progression of NPC. In this research the meta-signature miRNA identified may be used to develop a series of diagnostic and prognostic biomarkers for NPC that serve specificity for use in clinics.

References

May 18, 2004·Cancer Cell·Kwok Wai LoDolly P Huang
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Srikumar SenguptaPaul Ahlquist
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jan 31, 2009·The American Journal of Pathology·Geoffrey ChildsNicolas F Schlecht
Dec 23, 2009·The International Journal of Biochemistry & Cell Biology·William C S Cho
Mar 5, 2011·Oncology Reports·Ting LiYao Li
Jan 3, 2012·International Journal of Radiation Oncology, Biology, Physics·Juanjuan OuHoujie Liang
Jan 17, 2012·Bioinformatics·Raivo KoldeJaak Vilo
Dec 3, 2013·Journal of Experimental & Clinical Cancer Research : CR·Ming-Zhe MaCheng-Hong Peng
Jan 8, 2014·Journal of Translational Medicine·Jordan L PlieskattJason P Mulvenna
Jan 15, 2014·Journal of Oral & Maxillofacial Research·Dan ChenXiaofeng Zhou
Feb 25, 2014·Clinical Chemistry·Hai-Yun WangJian-Yong Shao
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Nowroji KavithaSreenivasan Sasidharan
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jin-Feng TangGang Liu
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Nov 25, 2014·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 24, 2015·The International Journal of Biochemistry & Cell Biology·Ya-Fei XuNa Liu
Dec 15, 2015·Genetics and Molecular Research : GMR·Y H CaoB Huang

❮ Previous
Next ❯

Citations

Jul 19, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Richard J LightbodyAnnette Graham
Aug 12, 2021·European Journal of Medical Research·Bingyu ZhangYing Sheng
Sep 28, 2021·Frontiers in Oncology·Shixiong WuShuo Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Software Mentioned

R
DAVID
Panther
TargetScan

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Urmo VõsaTarmo Annilo
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chu QinZhao-Xia Wang
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
J WuL Wang
© 2021 Meta ULC. All rights reserved