Meta-analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Heng ZhangYarong Wei

Abstract

The association between vitamin D deficiency and early spontaneous pregnancy loss (SPL) is unclear. To assess the association of serum 25-hydroxyvitamin D (25(OH)D) and SPL. Embase, PubMed, and Web of Science were searched for relevant papers published before February 20, 2016, using search terms including "vitamin D" and "pregnancy loss." Case-control and cohort studies investigating the relationship of maternal serum 25(OH)D and SPL were included. Two authors independently extracted original data from the selected papers. The DerSimonian-Laird random-effects model was used to perform the meta-analysis. Heterogeneity was assessed by calculating I2 . Five studies, including 10 630 pregnant women, met the inclusion criteria. There was no significant association between a low 25(OH)D level and an increased risk of SPL. In a subgroup analysis, an extremely low 25(OH)D level (<20 ng/mL) was significantly associated with an increased risk of SPL in the first trimester (relative risk 2.24, 95% confidence interval 1.15-4.37); the heterogeneity across studies was not significant (I2 =0.0%, P=0.355). Severe Vitamin D deficiency could be detrimental to early embryonic development and increase the risk of early SPL.

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Citations

Jul 28, 2018·American Journal of Reproductive Immunology : AJRI·Daniela Reis GonçalvesAntónio Marinho
Oct 17, 2018·International Journal of Environmental Research and Public Health·Stefan PilzWinfried März
Sep 11, 2018·Fertility and Sterility·Yu-Han ChiuIrene Souter
Jul 23, 2021·Fertility and Sterility·Nicole BanksAnne Z Steiner
Feb 27, 2021·Scientific Reports·Hubert WolskiAgnieszka Seremak-Mrozikiewicz
Dec 24, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·V E RadzinskyA A Orazmuradov

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