Meta-analysis of the effects of ischemic postconditioning on structural pathology in ST-segment elevation acute myocardial infarction

Oncotarget
Baohui LouMin Chen

Abstract

In this meta-analysis, we assessed cardiac magnetic resonance imaging data to determine the effects of local and remote ischemic postconditioning (LPoC and RPoC, respectively) on structural pathology in ST-segmentel elevation acute myocardial infarction (STEMI). We searched the Pubmed, Embase and Cochrane Library databases up to May 2017 and included 12 randomized controlled trials (10 LPoC and 2 RPoC)containing 1069 study subjects with thrombolysis in myocardial infarction flow grade 0~1. Weighed mean difference (WMD), standardized mean difference (SMD), and odds ratio (OR) were used for the pooled analysis. Random-effect model was used for the potential clinical inconsistency. LPoC and RPoC increased the myocardial salvage index (n= 5; weighted mean difference (WMD) = 5.52;P= 0.005; I2= 76.0%), and decreased myocardial edema (n= 7; WMD = -3.35;P= 0.0009; I2= 18.0%). However, LPoC and RPoC did not reduce the final infarct size (n= 10; WMD = -1.01;P> 0.05; I2= 68.0%), left ventricular volume (n= 10; standardized mean difference = 0.23;P> 0.05; I2= 93.0%), the incidence of microvascular obstruction (n= 6; OR = 0.99;P> 0.05; I2= 0.0%) or the extent of microvascular obstruction (n= 3; WMD = -0.09;P> 0.05; I2= 6.0%). This meta-anal...Continue Reading

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Citations

Mar 25, 2019·Cardiovascular Research·Melanie ZieglerKarlheinz Peter
Nov 14, 2020·Anesthesia and Analgesia·Sebastian RothBenedikt Preckel
May 19, 2021·Equine Veterinary Journal·Nicole VerhaarSabine Kästner

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