Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery.

BJS Open
J LawlerM Sugrue

Abstract

Cancer outcomes are complex, involving prevention, early detection and optimal multidisciplinary care. Postoperative infection and surgical site-infection (SSI) are not only uncomfortable for patients and costly, but may also be associated with poor oncological outcomes. A meta-analysis was undertaken to assess the oncological effects of SSI in patients with colorectal cancer. An ethically approved PROSPERO-registered meta-analysis was conducted following PRISMA guidelines. PubMed and Scopus databases were searched for studies published between 2007 and 2017 reporting the effects of postoperative infective complications on oncological survival in colorectal cancer. Results were separated into those for SSI and those concerning anastomotic leakage. Articles with a Methodological Index for Non-Randomized Studies score of at least 18 were included. Hazard ratios (HRs) with 95 per cent confidence intervals were computed for risk factors using an observed to expected and variance fixed-effect model. Of 5027 articles were reviewed, 43 met the inclusion criteria, with a total of 154 981 patients. Infective complications had significant negative effects on overall survival (HR 1·37, 95 per cent c.i. 1·28 to 1·46) and cancer-specific su...Continue Reading

References

Mar 1, 1992·Diseases of the Colon and Rectum·P GertschH J Altermatt
Aug 26, 1998·Archives of Surgery·R J HealdJ K MacFarlane
Nov 21, 1998·Diseases of the Colon and Rectum·D C JennerM D Levitt
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Mar 29, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wai Lun LawChi Leung Seto
Aug 3, 2007·The British Journal of Surgery·H PtokUNKNOWN Study Group Colon/Rectum Carcinoma (Primary Tumour)
Apr 15, 2008·Diseases of the Colon and Rectum·Sang Hun JungJin Cheon Kim
Jan 30, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C A BertelsenUNKNOWN Danish Colorectal Cancer Group
Feb 21, 2009·Journal of the American College of Surgeons·T Peter Kingham, H Leon Pachter
Mar 24, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F MarraM Zünd
May 15, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C A BertelsenUNKNOWN Danish Colorectal Cancer Group
Sep 25, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R KubeUNKNOWN Study group Qualitätssicherung Kolon/Rektum-Karzinome (Primärtumor) (Quality assurance in primary colorectal carcinoma)
Nov 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F JörgrenG Lindmark
Nov 19, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroshi KatohMasahiko Watanabe
Mar 10, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Molly M ConeKim C Lu
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rolf SauerClaus Rödel
Aug 8, 2012·American Journal of Clinical Oncology·Daniel J RenoufHagen Kennecke
Dec 12, 2012·Diseases of the Colon and Rectum·Karl MrakJörg Tschmelitsch
Jan 10, 2014·Diseases of the Colon and Rectum·Alexander T HawkinsLiliana Bordeianou
Jan 16, 2014·The Indian Journal of Surgery·Rakesh Kumar GuptaPanna Lal Sah
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Ping GongDong-Feng Wang
Sep 14, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel I ChuElizabeth B Habermann
Oct 17, 2014·World Journal of Gastroenterology : WJG·Regina AttiêVladmir Cláudio Cordeiro de Lima
Jan 27, 2015·The British Journal of Surgery·E EspínUNKNOWN Spanish Rectal Cancer Project
Aug 8, 2015·International Journal of Colorectal Disease·Sabrina M EbingerLukas Marti
Sep 24, 2015·Oncotarget·Olof JannaschPawel Mroczkowski

❮ Previous
Next ❯

Software Mentioned

INTERREG
MedCalc®
Review Manager ( RevMan )
MINORS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.