Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

The British Journal of Surgery
A MehrabiM W Büchler

Abstract

Emerging evidence suggests that the perioperative platelet count (PLT) can predict posthepatectomy liver failure (PHLF). In this systematic review and meta-analysis, the impact of perioperative PLT on PHLF and mortality was evaluated. MEDLINE and Web of Science databases were searched systematically for relevant literature up to January 2018. All studies comparing PHLF or mortality in patients with a low versus high perioperative PLT were included. Study quality was assessed using methodological index for non-randomized studies (MINORS) criteria. Meta-analyses were performed using Mantel-Haenszel tests with a random-effects model, and presented as odds ratios (ORs) with 95 per cent confidence intervals. Thirteen studies containing 5260 patients were included in the meta-analysis. Two different cut-off values for PLT were used: 150 and 100/nl. Patients with a perioperative PLT below 150/nl had higher PHLF (4 studies, 817 patients; OR 4·79, 95 per cent c.i. 2·89 to 7·94) and mortality (4 studies, 3307 patients; OR 3·78, 1·48 to 9·62) rates than patients with a perioperative PLT of 150/nl or more. Similarly, patients with a PLT below 100/nl had a significantly higher risk of PHLF (4 studies, 949 patients; OR 4·65, 2·60 to 8·31) an...Continue Reading

References

Nov 5, 2005·World Journal of Gastroenterology : WJG·Kazuhiro KanekoKatsuyoshi Hatakeyama
Apr 8, 2006·Science·Mickael LesurtelPierre-Alain Clavien
Oct 27, 2006·Molecular Biology of the Cell·Qiansheng RenSidney W Whiteheart
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio NocitoPierre-Alain Clavien
May 8, 2007·Journal of the American College of Surgeons·John T MullenJean-Nicolas Vauthey
Jun 15, 2007·Journal of Cellular Physiology·George K Michalopoulos
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Jan 21, 2009·Archives of Surgery·Takeaki IshizawaMasatoshi Makuuchi
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Feb 18, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mirko Moreno ZaldivarHermann E Wasmuth
Apr 16, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Simon A W G DelloCornelis H C Dejong
Aug 6, 2011·Blood·Sidney W Whiteheart
Apr 17, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Salvatore GruttadauriaBruno Gridelli
Nov 28, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick StarlingerThomas Gruenberger
May 16, 2014·JAMA : the Journal of the American Medical Association·Carol-Anne MoultonSteven Gallinger
Aug 3, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F RattiL Aldrighetti
Sep 11, 2014·World Journal of Gastroenterology : WJG·Hai-Qing WangLu-Nan Yan
Dec 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edris M AlkozaiTon Lisman
Jul 15, 2015·World Journal of Gastroenterology : WJG·Qing PangChang Liu
Sep 28, 2015·The Journal of Surgical Research·Raghunandan VenkatFelipe B Maegawa
Nov 4, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick StarlingerAlice Assinger
May 18, 2016·The Tohoku Journal of Experimental Medicine·Kazuhiro TakahashiNobuhiro Ohkohchi
May 2, 2017·The Journal of Surgical Research·Zhaohui ZhangBaogang Peng
Dec 6, 2018·Canadian Journal of Gastroenterology & Hepatology·Mohammad GolrizArianeb Mehrabi

❮ Previous
Next ❯

Citations

Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Bibek AryalYutaka Imoto
Nov 14, 2019·Surgery Today·Kazuhiro TakahashiNobuhiro Ohkohchi
Dec 6, 2018·Canadian Journal of Gastroenterology & Hepatology·Mohammad GolrizArianeb Mehrabi
Jul 16, 2019·Hepatology Communications·Alexandre BalaphasLeo H Bühler
Jan 31, 2020·BMC Surgery·Tanja KnoblichKatrin Hoffmann
Mar 23, 2021·World Journal of Clinical Cases·Ying XingMao-Min Song
Jun 9, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Abdullah KisaogluBulent Aydinli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.