Meta-analysis of the risks of hypertension and QTc prolongation in patients with advanced non-small cell lung cancer who were receiving vandetanib

European Journal of Clinical Pharmacology
Ying LiuGuo-Gang Xu

Abstract

A meta-analysis of published data was conducted to investigate the overall risks of hypertension and QTc prolongation in patients with advanced non-small cell lung cancer (NSCLC) who were receiving vandetanib. A computerized search through electronic databases, including PubMed and Embase (until Dec 2014), was performed to obtain eligible randomized controlled trials (RCTs) that compared hypertension and/or QTc prolongation profile of vandetanib alone or plus chemotherapy with control groups (placebo, single targeted therapy, chemotherapy, or a combination of them) in patients with advanced NSCLC. The outcome measures were the overall risks of hypertension and QTc prolongation. Relative risk (RR) and 95% confidence interval (CI) were calculated and pooled using a random effects model. A total of nine RCTs, which involved 4813 patients, were enrolled in the present study. A significant increase in risk was observed for all-grade hypertension (RR 5.58; 95% CI 4.16 to 7.48; P < 0.00001) and grade ≥3 hypertension (RR 4.79; 95% CI 2.31 to 9.93; P < 0.0001) in advanced NSCLC patients who were receiving vandetanib compared with the controls. Moreover, vandetanib significantly prolonged all-grade QTc interval (RR 7.90; 95% CI 4.03 to 1...Continue Reading

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Citations

Dec 9, 2017·Journal of the American Heart Association·Andreu Porta-SánchezPaaladinesh Thavendiranathan
Jan 10, 2019·Journal of Hypertension·Vasiliki KatsiDimitrios Tousoulis
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Nov 2, 2019·Journal of Cardiovascular Translational Research·Mohammed Alomar, Michael G Fradley
Jul 10, 2021·Clinical Science·Aristeidis SionakidisSandosh Padmanabhan

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