PMID: 20491052May 22, 2010

Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure

European Journal of Ophthalmology
Princeton Wen-Yuan LeeW C Stewart

Abstract

To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been ≥2 weeks with ≥19 patients per treatment arm for a crossover, and ≥50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p≤0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p≤0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05). This meta-...Continue Reading

References

Jan 1, 1995·Ophthalmology·S L GrahamF S Mikelberg
Dec 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H J KaiserD Stümpfig
Oct 1, 1996·The British Journal of Ophthalmology·J H MeyerJ Funk
Oct 8, 1999·American Journal of Ophthalmology·S S HayrehM B Zimmerman
Nov 13, 2001·American Journal of Ophthalmology·D GherghelJ Flammer
Nov 14, 2002·American Journal of Ophthalmology·Paul J Lama
Sep 15, 2004·American Journal of Ophthalmology·John H K LiuRobert N Weinreb
Jan 27, 2005·Investigative Ophthalmology & Visual Science·Mitra SehiGraham E Trope
Nov 15, 2006·Archives of Ophthalmology·A G P KonstasW C Stewart
Sep 27, 2007·The British Journal of Ophthalmology·W C StewartMarko A Mychaskiw
Nov 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ciro CostagliolaAdolfo Sebastiani

Citations

Feb 26, 2016·Advances in Therapy·A G P KonstasStefano Miglior
Mar 19, 2019·Current Medical Research and Opinion·George RennieGiovanni Strippoli
Nov 7, 2019·Journal of Glaucoma·Lauren CiullaAlon Harris

Related Concepts

Administration, Topical
Adrenergic beta-Antagonists
Diastolic Blood Pressure
Circadian Rhythms
Glaucoma, Open-Angle
Physiologic Intraocular Pressure
Ocular Hypertension
Ophthalmic Solution
Timoptol
Intraocular Pressure Test

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