PMID: 20491052May 22, 2010

Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure

European Journal of Ophthalmology
Princeton Wen-Yuan LeeW C Stewart


To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been ≥2 weeks with ≥19 patients per treatment arm for a crossover, and ≥50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p≤0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p≤0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05). This meta-...Continue Reading


Jan 1, 1995·Ophthalmology·S L GrahamF S Mikelberg
Dec 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H J KaiserD Stümpfig
Oct 1, 1996·The British Journal of Ophthalmology·J H MeyerJ Funk
Oct 8, 1999·American Journal of Ophthalmology·S S HayrehM B Zimmerman
Nov 13, 2001·American Journal of Ophthalmology·D GherghelJ Flammer
Nov 14, 2002·American Journal of Ophthalmology·Paul J Lama
Sep 15, 2004·American Journal of Ophthalmology·John H K LiuRobert N Weinreb
Jan 27, 2005·Investigative Ophthalmology & Visual Science·Mitra SehiGraham E Trope
Nov 15, 2006·Archives of Ophthalmology·A G P KonstasW C Stewart
Sep 27, 2007·The British Journal of Ophthalmology·W C StewartMarko A Mychaskiw
Nov 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ciro CostagliolaAdolfo Sebastiani


Feb 26, 2016·Advances in Therapy·A G P KonstasStefano Miglior
Mar 19, 2019·Current Medical Research and Opinion·George RennieGiovanni Strippoli
Nov 7, 2019·Journal of Glaucoma·Lauren CiullaAlon Harris

Related Concepts

Administration, Topical
Adrenergic beta-Antagonists
Diastolic Blood Pressure
Circadian Rhythms
Glaucoma, Open-Angle
Physiologic Intraocular Pressure
Ocular Hypertension
Ophthalmic Solution
Intraocular Pressure Test

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.