Meta-analysis on the association between toothbrushing and head and neck cancer

Oral Oncology
Xian-Tao ZengWei Huang

Abstract

Epidemiological studies have focused on the association between toothbrushing and head and neck cancer (HNC). However, the question of whether toothbrushing is associated with decreased risk of HNC remains unanswered. Since there is currently no systematic review or meta-analysis available to provide quantitative findings on this important clinical question; we consequently performed this meta-analysis to investigate the association between toothbrushing and HNC risk. We searched PubMed and Embase up to January 13 (updated on October 20), 2014 to identify observational studies that investigated the association between toothbrushing and HNC. After study section and data extraction, the meta-analysis was conducted using RevMan 5.2 software. A total of 18 case-control studies involving 7068 cases and 9990 controls were included. The meta-analysis showed that compared with highest toothbrushing frequency, lowest level was significantly increased risk of HNC 2.08 times (odds ratio=2.08, 95% confidence interval=1.65-2.62). This significant association remained consistent after adjusting for smoking status and alcohol consumption. No publication bias was detected. This meta-analysis found frequency of toothbrushing was significantly a...Continue Reading

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Citations

Dec 8, 2015·International Journal of Cardiology·Xian-Tao ZengJoey S W Kwong
Jun 25, 2015·Journal of Evidence-based Medicine·Sheng LiXian-Tao Zeng
Jun 14, 2016·Journal of Periodontology·Xian-Tao ZengJoey S W Kwong
Feb 9, 2017·Frontiers in Physiology·Hong WengXing-Huan Wang
Mar 14, 2019·Cancer Medicine·Chan-Chi ChangJeffrey S Chang
Feb 14, 2019·Diabetes/metabolism Research and Reviews·Wenning FuShiyi Cao
Apr 6, 2019·Indian Journal of Surgical Oncology·Rachit MathurPankaj Chaturvedi
Jul 25, 2019·Frontiers in Cellular and Infection Microbiology·Lili WangZhigang Huang
Dec 23, 2020·European Journal of Clinical Investigation·Huadong WuBaojun Zhou

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