Meta-analysis on the effects of octreotide on tumor mass in acromegaly.

PloS One
A GiustinaShlomo Melmed

Abstract

The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower growth hormone (GH) levels in patients with acromegaly and may also induce pituitary tumor shrinkage. We performed a meta-analysis to accurately assess the effect of octreotide on pituitary tumor shrinkage. A computerized Medline and Embase search was undertaken to identify potentially eligible studies. Eligibility criteria included treatment with octreotide, availability of numerical metrics on tumor shrinkage and clear definition of a clinically relevant reduction in tumor size. Primary endpoints included the proportion of patients with tumor shrinkage and mean percentage reduction in tumor volume. The electronic search identified 2202 articles. Of these, 41 studies fulfilling the eligibility criteria were selected for data extraction and analysis. In total, 1685 patients were included, ranging from 6 to 189 patients per trial. For the analysis of the effect of octreotide on pituitary tumor shrinkage a random effect model was used to account for differences in both effect size and sampling error. Octreotide was shown to induce tumor shrinkage in 53.0% [95% CI: 45.0%-61.0%] of treated patients. In patients treated with th...Continue Reading

References

Nov 1, 1992·Annals of Internal Medicine·S EzzatD M Cook
Sep 1, 1992·Metabolism: Clinical and Experimental·A StevenaertA Beckers
Sep 1, 1992·Endocrinology and Metabolism Clinics of North America
Jul 1, 1992·Journal of Computer Assisted Tomography·P Lundin, F Pedersen
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·P G ChiodiniE del Pozo
Oct 1, 1988·Endocrinologia Japonica·R HorikawaY Ohba
Aug 1, 1996·Metabolism: Clinical and Experimental·I LancranjanL Simionescu
Jun 1, 1996·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A K FløgstadJ Jervell
Nov 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A GiustinaW B Wehrenberg
Feb 1, 1997·Australian and New Zealand Journal of Medicine·N W CheungS C Boyages
Nov 5, 1997·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Sep 12, 1998·Annals of Internal Medicine·I Shimon, S Melmed
Sep 24, 1998·The Journal of Clinical Endocrinology and Metabolism·C B NewmanD L Kleinberg
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M J Naidich, E J Russell
Apr 29, 1999·Journal of Endocrinological Investigation·A ColaoG Lombardi
Feb 26, 2000·The Journal of Clinical Endocrinology and Metabolism·A GiustinaS Melmed
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Renato CozziAlberto M Pedroncelli
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·John S Bevan
Apr 14, 2005·The Journal of Clinical Endocrinology and Metabolism·Shlomo MelmedAriel Barkan
May 12, 2005·The Journal of Clinical Endocrinology and Metabolism·Pamela U FredaDaniel Rabinowitz
Jun 14, 2005·Journal of Clinical Pharmacology·Beatrice AstrucMichael Sheppard
Aug 3, 2005·Clinical Endocrinology·Raquel S JalladMarcello D Bronstein
Dec 3, 2005·European Journal of Endocrinology·S MelmedA Giustina
Mar 24, 2006·Journal of Endocrinological Investigation·M GolaA Giustina
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Vivien S Bonert, Shlomo Melmed
Dec 15, 2006·The New England Journal of Medicine·Shlomo Melmed
Feb 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Patrick MaisonPhilippe Chanson

❮ Previous
Next ❯

Citations

Oct 23, 2013·European Journal of Endocrinology·Marianne Andersen
Feb 26, 2014·Nature Reviews. Endocrinology·Andrea GiustinaUNKNOWN Acromegaly Consensus Group
Nov 26, 2013·Pituitary·Lucio VilarMarcello D Bronstein
Feb 8, 2014·Endocrine·Leandro KasukiMônica R Gadelha
May 13, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luciano QuarantaAnastasios G P Konstas
Mar 22, 2014·Journal of Molecular Endocrinology·Daniel Cuevas-Ramos, Maria Fleseriu
Jun 20, 2014·Nuclear Medicine Communications·Andrea GiustinaRaffaele Giubbini
Oct 30, 2013·Pituitary·Ana Laura Espinosa de los MonterosMoisés Mercado
Sep 24, 2014·Journal of Endocrinological Investigation·A GiustinaR Pivonello
Jul 27, 2012·Endocrine·Michael Buchfelder, Sven-Martin Schlaffer
Jun 29, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Maria Fleseriu
Oct 16, 2013·Expert Opinion on Pharmacotherapy·Andrea GiustinaGherardo Mazziotti
Jul 23, 2013·Frontiers in Neuroendocrinology·Marily Theodoropoulou, Günter K Stalla
May 15, 2015·Early Human Development·Daniela TestoniUNKNOWN Best Pharmaceuticals for Children Act — Pediatric Trials Network Administrative Core Committee
Nov 28, 2015·Nature Reviews. Endocrinology·Shlomo Melmed
Feb 5, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Antonio PisaniUNKNOWN ALADIN Study Group
Jul 19, 2012·Clinical Endocrinology·Andrea Giustina
Aug 25, 2015·European Journal of Internal Medicine·Luis Margusino-FramiñánFernando Cordido
Jul 3, 2015·The Journal of Endocrinology·Cristina Capatina, John A H Wass
Nov 7, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shlomo MelmedMaria Fleseriu
Jun 29, 2016·Expert Opinion on Pharmacotherapy·Filippo MaffezzoniAndrea Giustina
Dec 18, 2016·Pituitary·Daniel A DonohoJohn D Carmichael
Apr 19, 2017·The Journal of Clinical Endocrinology and Metabolism·Andrea GiustinaEzio Ghigo
Feb 27, 2016·F1000Research·Georgia Ntali, Niki Karavitaki
Sep 12, 2018·Journal of the Endocrine Society·Stefano FraraAndrea Giustina
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Jan 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Eva C CoopmansSebastian J C M M Neggers
Jan 19, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shereen EzzatStan Van Uum
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Philippe J CaronUNKNOWN PRIMARYS Investigators
Mar 13, 2014·The Journal of Clinical Endocrinology and Metabolism·John D CarmichaelShlomo Melmed

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
surgical resection

Software Mentioned

SAS
SAS System
GRAPH Annotate

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.