May 5, 2016

Meta-analysis reveals pathway signature of Septic Shock

BioRxiv : the Preprint Server for Biology
Samanwoy MukhopadhyaySaroj K Mohapatra

Abstract

Background: Septic shock is a major medical problem with high morbidity and mortality and incompletely understood biology. Availability of genome-wide expression data from different studies on septic shock empowers the quest for hitherto unidentified pathways by integration and meta-analysis of multiple data sets. Methods: Electronic search was performed on medical literature and gene expression databases. Selection of studies was based on the organism (human subjects), tissue of origin (circulating leukocytes) and the platform technology (gene expression microarray). Gene-level meta-analysis was conducted on the six selected studies to identify the genes consistently differentially expressed in septic shock. These genes were then subjected to pathway analysis. Results: The identified up-regulated pathway hsa04380 (Osteoclast Differentiation) was validated in an independent cohort of patients. A simplified model was generated showing the major gene-modules dysregulated in SS. Conclusions: In the light of this finding, altered osteoclast differentiation in septic shock deserves greater attention. Keywords: Septic Shock; Genome-wide Gene Expression; hsa04380; Osteoclast differentiation; Meta-analysis; Pathway Analysis

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Mentioned in this Paper

Study
Biochemical Pathway
Morbidity Aspects
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Genome
Genes
Research Subject
White Blood Cell Count Procedure
Gene Expression

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