Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population

Autoimmunity
Gowher NabiShafiul Haque

Abstract

The PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis (RA). However, reports from the Asian populations are conflicting in nature and lacks consensus. The aim of our study was to evaluate the association between the PTPN22 1858C/T polymorphism and RA in Asian and Caucasian subjects by carrying out a meta-analysis of Asian and Caucasian data. A total of 27 205 RA cases and 27 677 controls were considered in the present meta-analysis involving eight Asian and 35 Caucasian studies. The pooled odds ratios (ORs) were performed for the allele, dominant, and recessive genetic model. No statistically significant association was found between the PTPN22 1858C/T polymorphism and risk of RA in Asian population (allele genetic model: OR = 1.217, 95% confidence interval (CI) = 0.99-1.496, p value 0.061; dominant genetic model: OR = 1.238, 95% CI = 0.982-1.562, p value 0.071; recessive genetic model: OR = 1.964, 95% CI = 0.678-5.693, p value 0.213). A significant association with risk of RA in Caucasian population suggesting that T-- allele does confer susceptibility to RA in this subgroup was observed (allele genetic model: OR = 1.638, 95% CI = 1.574-1.705, p value < 0.0001; dominant genetic model: OR = 1.67, 95% CI = 1.59...Continue Reading

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Citations

Dec 13, 2018·Current Opinion in Rheumatology·Eva SchrezenmeierThomas Dörner
Apr 3, 2019·Molecular Genetics & Genomic Medicine·Natalia Wawrusiewicz-KurylonekAdam Jacek Krętowski
Apr 26, 2020·The Journal of Gene Medicine·Mitra AbbasifardZahra Bagheri-Hosseinabadi
Feb 18, 2017·International Journal of Genomics·Yeniley Ruiz-NoaJosé Francisco Muñoz-Valle
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Nov 30, 2018·Physiological Research·D VejrazkovaB Bendlova
May 31, 2017·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Nov 25, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·María Elena SotoJulian Ramírez-Bello
Jul 9, 2020·Rheumatology·Laura E Dedmon
Aug 28, 2021·International Journal of Molecular Sciences·Teppei HashimotoKiyoshi Matsui

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