Meta-analysis showing that early response to neoadjuvant chemotherapy predicts better survival among cervical cancer patients

Zhilan ChenQiping Lu


This study was designed to identify the prognostic value of early response to neoadjuvant chemotherapy (NACT) for long-term survival of cervical cancer patients. We searched Pubmed and EMBASE for studies published through July 2016 on outcomes of cervical patients that received NACT. Eight studies involving 825 cervical cancer patients were ultimately included in our meta-analysis. We pooled the hazard ratios (HR) according to random-effects models and used funnel plots with Egger's and Begg's tests to explore potential publication bias. The HR between early response and 1-year overall survival (OS) was 3.60 (95% CI 1.93-6.72; I(2) = 0). Similar results were found in the analysis of 3-year OS (HR 3.34; 95% CI 2.28-4.90; I(2) = 0) and 5-year OS (HR 3.44; 95% CI 2.40-4.94; I(2) = 0). Sensitivity analysis showed that all of the pooled results were robust, and all logHRs had confidence limits > 0. Our findings indicate that early response is associated with long-term survival, and responders achieved a higher survival rate than non-responders.


Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Vincenzo ValentiniMaurizio Cosimelli
Oct 31, 2002·Statistics in Medicine·Paula R WilliamsonAnthony G Marson
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Juan E SardiJuan J Sardi
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L SelvaggiG Cormio
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
Jul 4, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dong Choon ParkSeung Geun Yeo
Jul 14, 2010·The Lancet Oncology·Lukas RobHelena Robova
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taisuke MoriJo Kitawaki
Feb 14, 2012·Lancet·Philippe MoriceChristine Haie-Meder
Apr 17, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ting HuDing Ma
Oct 16, 2012·Gynecologic Oncology·Helena RobovaMatej Komar
Jan 17, 2014·The New England Journal of Medicine·Deirdre K TobiasFrank B Hu
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 22, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F MartinelliF Raspagliesi
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
May 4, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ana Morais SebastiãoMaria Del Pilar Estevez Diz
Jun 15, 2016·The Lancet Oncology·Enrica BentivegnaPhilippe Morice

❮ Previous
Next ❯


Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Florencia NollFernando Heredia
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Javier BurbanoJuliana Rodriguez

❮ Previous
Next ❯

Software Mentioned

Engauge Digitizer

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.