Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis

European Journal of Epidemiology
Yukari Watanabe, Takamitsu Watanabe

Abstract

Head injury is considered as a potential risk factor for amyotrophic lateral sclerosis (ALS). However, several recent studies have suggested that head injury is not a cause, but a consequence of latent ALS. We aimed to evaluate such a possibility of reverse causation with meta-analyses considering time lags between the incidence of head injuries and the occurrence of ALS. We searched Medline and Web of Science for case-control, cross-sectional, or cohort studies that quantitatively investigated the head-injury-related risk of ALS and were published until 1 December 2016. After selecting appropriate publications based on PRISMA statement, we performed random-effects meta-analyses to calculate odds ratios (ORs) and 95% confidence intervals (CI). Sixteen of 825 studies fulfilled the eligibility criteria. The association between head injuries and ALS was statistically significant when the meta-analysis included all the 16 studies (OR 1.45, 95% CI 1.21-1.74). However, in the meta-analyses considering the time lags between the experience of head injuries and diagnosis of ALS, the association was weaker (OR 1.21, 95% CI 1.01-1.46, time lag ≥ 1 year) or not significant (e.g. OR 1.16, 95% CI 0.84-1.59, time lag ≥ 3 years). Although it d...Continue Reading

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Citations

Jul 29, 2018·Journal of Neurology·Kevin TalbotMartin R Turner
Nov 16, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Francesca PaleseFederica Edith Pisa
Jan 19, 2019·Journal of Neuropathology and Experimental Neurology·Joshua SchwartzenburgShyamal Desai
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May 2, 2018·International Journal of Biometeorology·Javier RianchoAna Santurtun
Jan 12, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Dongqing GuGuodong Liu
Aug 9, 2021·Biological Psychiatry·Benjamin L BrettC Dirk Keene
Jan 28, 2022·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Marie BeaudinNicolas Dupré

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