PMID: 2104758Jan 19, 1990Paper

Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation)

Biochimica Et Biophysica Acta
C LoesbergL Smets

Abstract

Meta-iodobenzylguanidine (MIBG) is a guanidine analogue of the neurotransmitter norepinephrine. Radioiodinated [131I]MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Moreover, non-radiolabelled MIBG exerts several cell-biological effects, tentatively ascribed to interference with cellular mono(ADP-ribosyl) transferases (Smets, L.A., Bout, B. and Wisse, J. (1988) Cancer Chemother. Pharmacol. 21, 9-13; Smets, L.A., Metwally, E.A.G., Knol, E. and Martens, M. (1988) Leukemia Res. 12, 737-743). In the present study it was investigated whether MIBG could serve as an acceptor for the ribosyl transferase activity of cholera toxin and of erythrocyte membranes. MIBG appeared a substrate for the cholera toxin-catalyzed transfer of the ADP-ribose moiety of NAD to arginine-like residues with the highest affinity for this enzyme reported as yet (Km = 6.5 microM). MIBG was also ADP-ribosylated by the mono(ADP-ribosyl)transferase(s) of turkey erythrocyte membranes. Moreover, the drug appeared a potent affector of the ADP-ribose linkage to membrane proteins by these enzymes. Interference by MIBG was stronger than by related guanyltyramine, the monoamine precursors of MIBG, meta...Continue Reading

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Citations

Jul 24, 2010·Amino Acids·Sabrina LaingFriedrich Haag
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J CornelissenA H Van Gennip
Dec 9, 1998·International Journal of Radiation Oncology, Biology, Physics·J E BiaglowS M Evans
Nov 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carlos W NossaSteven R Blanke
Jan 13, 2010·The Journal of Biological Chemistry·Olga LosevaThomas Helleday
Feb 14, 1995·Biochemical Pharmacology·J CornelissenA B Van Kuilenburg
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·M RutgersL A Smets
Aug 15, 1990·International Journal of Cancer. Journal International Du Cancer·C LoesbergL A Smets
Jun 28, 2014·International Journal of Molecular Medicine·Yan SuYa-Lan Wang
Jun 11, 1993·Biochimica Et Biophysica Acta·S J Child, D E Hruby

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