Meta-linked poly(phenylene ethynylene) conjugated polyelectrolyte featuring a chiral side group: helical folding and guest binding

Langmuir : the ACS Journal of Surfaces and Colloids
Xiaoyong Zhao, Kirk S Schanze

Abstract

A water soluble, meta-linked poly(phenylene ethynylene) featuring chiral and optically active side groups based on L-alanine (mPPE-Ala) has been studied by using absorption, fluorescence, and circular dichroism spectroscopy. Studies of mPPE-Ala in methanol/water solvent mixtures show that the polymer folds into a helical conformation, and the extent of helical folding increases with the volume % water in the solvent. The presence of the helical conformation is signaled by the appearance of a broad, excimer-like visible fluorescence band, combined with a strong bisignate circular dichroism signal in the region of the pi,pi absorption of the polymer backbone. The circular dichroism signal exhibits negative chirality, suggesting that the left-handed (M-form) of the helix is in enantiomeric excess. Binding of the metallointercalator [Ru(bpy)2(dppz)]2+ (where bpy = 2,2-bipyridine and dppz = dipyrido[3,2-a:2',3'-c]phenazine) with the helical polymer is accompanied by the appearance of the orange-red photoluminescence from the metal complex. This effect is directly analogous to that observed when [Ru(bpy)2(dppz)]2+ binds to DNA via intercalation, suggesting that the metal complex binds to mPPE-Ala by intercalating between the pi-stack...Continue Reading

References

Sep 20, 1997·Science·J C NelsonP G Wolynes
Jan 29, 2000·Angewandte Chemie·R B PrinceJ S Moore
Jul 27, 2001·Journal of the American Chemical Society·K I ShinoharaH Shigekawa
Dec 13, 2001·Chemical Reviews·T Nakano, Y Okamoto
Dec 13, 2001·Chemical Reviews·J J CornelissenN A Sommerdijk
Jul 4, 2002·Journal of the American Chemical Society·Hidetoshi Goto, Eiji Yashima
Nov 16, 2002·Angewandte Chemie·Steffen Zahn, Timothy M Swager

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Citations

Aug 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Dongping XieKirk S Schanze
Oct 12, 2010·Chemical Communications : Chem Comm·Kizhumuri P DivyaAyyappanpillai Ajayaghosh
May 11, 2011·Organic & Biomolecular Chemistry·Katy CantinJean-Francois Morin
Oct 9, 2012·Chemical Communications : Chem Comm·Jinxin CaoBing Gong
May 16, 2009·Angewandte Chemie·Hui JiangKirk S Schanze
Aug 7, 2009·Chemistry : a European Journal·Ying WangHua Jiang
Nov 20, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Xuzhi ZhuKirk S Schanze
Dec 23, 2017·Macromolecular Bioscience·Tamara Abou Matar, Pierre Karam
Mar 29, 2012·Chemical Communications : Chem Comm·Sakiko SuzukiToshikazu Takata
Nov 1, 2008·Organic Letters·Veluru Ramesh NaiduKyu-Sung Jeong
Nov 13, 2009·Chemical Reviews·Eiji YashimaKanji Nagai
Aug 24, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Eunkyung JiKirk S Schanze
Jun 21, 2012·The Journal of Physical Chemistry Letters·Fude FengKirk S Schanze
Jun 21, 2012·The Journal of Physical Chemistry Letters·Danlu WuKirk S Schanze

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