Metaanalysis of statins and survival in de novo cardiac transplantation

Transplantation Proceedings
Mandeep R Mehra, N Y Raval

Abstract

The use of HMG CoA reductase inhibitors (statins) after cardiac transplantation has been suggested to decrease the incidence of severe rejection and improve survival. Individual investigations that have led to this suggestion are randomized (but not placebo-controlled) studies, including small patient numbers that have (and thus underpowered) and enrolling heterogeneous subjects (including retransplant recipients). The purpose of this pooled analysis was to quantify the benefit of statins on survival in de novo cardiac transplant recipients. Medline (1966 to 2003) was queried using the keywords statin, HMG CoA reductase inhibitors, cardiac transplantation, transplant, cholesterol, atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. In addition, we searched the cited literature and previously published systematic reviews. Of 36 articles retrieved, 3 randomized controlled studies met our population inclusion criteria; namely age >18 years, de novo heart transplant recipients, statin therapy within 3 months, and > or = 1-year follow-up. Pooled data were metaanalyzed by Mantel-Haenszel tests using a random effects model that included tests for heterogeneity. The three pooled studies included 246 patients (statin, n...Continue Reading

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Citations

May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Howard J EisenUNKNOWN Mycophenolate Mofetil Cardiac Study Investigators
Nov 9, 2012·Journal of Cardiovascular Translational Research·Monica Colvin-AdamsDaniel Duprez
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Aug 4, 2021·Heart·Juan M Ortega-Legaspi, Paco E Bravo
Dec 17, 2016·Current Opinion in Organ Transplantation·Jessamyn BagleyJohn Iacomini

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