Metabolic abnormalities characteristic of dysmetabolic syndrome predict the development of transplant coronary artery disease: a prospective study

Circulation
Hannah A ValantineE B Stinson

Abstract

This study examines the hypothesis that metabolic abnormalities of dysmetabolic syndrome are risk factors for transplant coronary artery disease (TxCAD). Sixty-six patients without overt diabetes, 2 to 4 years after surgery, underwent intracoronary ultrasound (ICUS), measurement of plasma glucose and insulin after oral glucose (75 g), and fasting lipid and lipoproteins. TxCAD incidence by angiography or autopsy was prospectively determined during subsequent follow-up (8 years). Coronary artery intimal thickness (IT) and subsequent outcomes were compared in patients stratified as having "high" versus "low" plasma glucose (>8.9 mmol/L) and insulin (>760 pmol/L) 2 hours after glucose challenge; and "abnormal" versus "normal" fasting lipid and lipoprotein concentrations as defined by the National Cholesterol Education Patients with high glucose or insulin concentrations had greater IT: 0.38+/-0.05 versus 0.22+/-0.02 mm, P</=0.05, and 0.39+/-0.05 versus 0.20+/-0.02 mm, P</=0.01, respectively. Freedom from TxCAD was 56+/-11% versus 81+/-6% (P<0.01) in patients with high versus low glucose and 57+/-10% versus 82+/-7% (P<0.05) in patients with high versus low insulin. Actuarial survival was 60+/-12% versus 92+/-5% (P<0.005) in patients...Continue Reading

References

Jul 7, 1989·JAMA : the Journal of the American Medical Association·C M BallantyneJ B Young
Nov 1, 1988·Diabetes/metabolism Reviews·G M Reaven, Y D Chen
Nov 15, 1995·Journal of the American College of Cardiology·M R MehraD D Stapleton
Sep 7, 1995·The New England Journal of Medicine·J A KobashigawaG A Cogert
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien

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Citations

Jul 31, 2009·Current Diabetes Reports·Vittoria BonatoMario Carmellini
Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mario SénéchalRichard Dorent
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roland KlingenbergThomas J Dengler
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Martin SilverbornFolke Nilsson
Sep 11, 2004·Journal of Clinical Epidemiology·Carl van WalravenGeorge A Wells
Aug 9, 2003·Journal of the American College of Cardiology·Aina HognestadArne K Andreassen
Aug 9, 2003·Journal of the American College of Cardiology·Hector O Ventura, Mandeep R Mehra
May 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R Mehra, Patricia A Uber
Jan 7, 2005·Seminars in Thoracic and Cardiovascular Surgery·Katherine Lietz, Leslie W Miller
Sep 15, 2005·The Journal of Cardiovascular Nursing·Frances M Hoffman
Dec 3, 2011·Transplantation·Juan Miguel Sánchez-GómezAntonio Salvador
Jul 20, 2007·Nephrology·Toshihide NaganumaTatsuya Nakatani
Jan 18, 2006·Annual Review of Medicine·Abdulaziz Al-khaldi, Robert C Robbins
Aug 22, 2014·Current Opinion in Organ Transplantation·Satish Arora, Lars Gullestad
Apr 29, 2014·Transplantation Proceedings·C-M LuoS-S Wang
Mar 19, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Neha SinghBart De Geest
Feb 8, 2011·Diabetes & Metabolism·A Räkel, A D Karelis
Jun 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Luis Martínez-DolzAntonio Salvador
Feb 6, 2008·The Nursing Clinics of North America·Annette De Vito Dabbs, Mi-Kyung Song
Apr 1, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aiko P J de VriesReinold O b Gans
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Phuong-Thu T PhamAlan H Wilkinson
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Luciano Potena, Hannah A Valantine
May 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mariana Markell
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Aiko P J de VriesReinold O B Gans
Apr 28, 2004·Clinical Transplantation·Mario SénéchalIradj Gandjbakhch
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hannah A Valantine
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R Mehra
Apr 4, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Yoshifumi IkedaReiner Koerfer
Feb 10, 2009·Clinical Transplantation·Pierre AmbrosiGilbert Habib
Feb 24, 2006·Journal of Cardiac Surgery·Steven R MeyerShaohua Wang
Jan 26, 2008·Clinical Transplantation·Jaime AgueroAntonio Salvador
Jul 25, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Luis Martínez-DolzJose Anastasio Montero
Jul 23, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Neha SinghBart De Geest
Jul 22, 2014·Journal of Cardiac Surgery·Kamel SadatWissam I Khalife
Feb 19, 2009·Clinical Transplantation·Milan LuknarJuraj Fabian
Jul 18, 2008·Transplantation Reviews·Roy D Bloom, Michael F Crutchlow
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eugenia R RaichlinRobert P Frantz
Apr 4, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ombretta BiadiHannah A Valantine
Apr 20, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hannah Valantine
Apr 20, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Piero Marchetti
Apr 20, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Anne Keogh
Apr 20, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Howard Eisen, Heather Ross
Apr 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Arja SiirtolaMatti K Salo

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