PMID: 15377073Sep 21, 2004Paper

Metabolic abnormalities in patients with HIV infection

Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
Sandra I Rodríguez-Carranza, Carlos A Aguilar-Salinas

Abstract

Highly active antiretroviral therapy (HAART) decreased the mortality of patients with HIV infection, but its effects on the metabolism of lipoproteins, carbohydrates and adipose tissue are a common cause for seeking treatment. Our purpose is to present the current knowledge available regarding the epidemiology, pathophysiology, diagnosis and treatment of these conditions. A discussion about the limitations of the current evidence is included. HIV-related dyslipidemia is multifactorial. Prior to the treatment, hypertriglyceridemia is found frequently, usually with low cholesterol and HDL cholesterol levels. Antiretroviral agents, especially some protease inhibitors, have adverse effects on plasma lipids. Nutritional recovery and lipodistrophy exacerbate the lipid abnormalities. Hypertriglyceridemia (usually moderate to severe) and moderate hypercholesterolemia (< 300 mg/dL) are the most common end-results. Subcutaneous fat of the face and limbs decreases and it is deposited in the neck and in the abdomen. The diagnosis and treatment of these conditions are controversial due to the lack of appropriate evidence. The metabolic complications of HAART could be a leading cause of mortality in the near future. Thus, longitudinal studie...Continue Reading

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Arquivos brasileiros de endocrinologia e metabologia
Angélica M M ValenteAntonio R Chacra
Journal of Endocrinological Investigation
E S MajaliwaF Chiarelli
Reviews in Endocrine & Metabolic Disorders
Ovidiu GalescuSvetlana Ten
Recent Patents on Anti-infective Drug Discovery
Koosha PaydaryMinoo Mohraz
© 2021 Meta ULC. All rights reserved