Metabolic acidosis aggravates experimental acute kidney injury

Life Sciences
Patrícia Andréa da Fonseca MagalhãesAlexandre Braga Libório

Abstract

Ischemia/reperfusion (I/R) injury and metabolic acidosis (MA) are two critical conditions that may simultaneously occur in clinical practice. The result of this combination can be harmful to the kidneys, but this issue has not been thoroughly investigated. The present study evaluated the influence of low systemic pH on various parameters of kidney function in rats that were subjected to an experimental model of renal I/R injury. Metabolic acidosis was induced in male Wistar rats by ingesting ammonium chloride (NH4Cl) in tap water, beginning 2 days before ischemic insult and maintained during the entire study. Ischemia/reperfusion was induced by clamping both renal arteries for 45 min, followed by 48 h of reperfusion. Four groups were studied: control (subjected to sham surgery, n=8), I/R (n=8), metabolic acidosis (MA; 0.28 M NH4Cl solution and sham surgery, n=6), and MA+I/R (0.28 M NH4Cl solution plus I/R, n=9). Compared with I/R rats, MA+I/R rats exhibited higher mortality (50 vs. 11%, p=0.03), significant reductions of blood pH, plasma bicarbonate (pBic), and standard base excess (SBE), with a severe decline in the glomerular filtration rate and tubular function. Microscopic tubular injury signals were detected. Immunofluores...Continue Reading

References

Aug 12, 1999·Cellular and Molecular Life Sciences : CMLS·J F ArnalJ Rami
Feb 7, 2001·Critical Care Medicine·H ShimizuR Akagi
Nov 13, 2001·Kidney International·H AmlalM Soleimani
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Kei TakeshitaKazuhiro Yamaguchi
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Magali de AraujoAntonio Carlos Seguro
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kellie L K TamashiroRandall R Sakai
Nov 27, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Prabal K Chatterjee
May 16, 2009·Basic Research in Cardiology·Antonio Rodríguez-SinovasDavid García-Dorado
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
Mar 12, 2011·The Journal of Surgical Research·Fei WangXiao-Ming Deng
Oct 18, 2012·JAMA : the Journal of the American Medical Association·Nor'azim Mohd YunosMichael Bailey
Jun 21, 2013·Clinical & Experimental Metastasis·Silvia PeppicelliLido Calorini
Aug 27, 2013·The Journal of Surgical Research·Yun-peng WangXin Ma
Aug 29, 2013·The Journal of Surgical Research·Changbin ChuXin Gou
Feb 6, 2012·World Journal of Nephrology·Matheus Correa-CostaNiels Olsen Saraiva Câmara
Nov 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Xiaoxi ZengSushrut S Waikar
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yan-Ying FanZhong Chen
Dec 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Meri PoukkanenUNKNOWN FINNAKI Study Group
Jul 12, 2014·Experimental Biology and Medicine·Wei GaoGuangxiao Cui
Sep 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammed Al-Jaghbeer, John A Kellum

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Citations

Jul 21, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kelly MercierSusan Sumner
Feb 7, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matthew F BarhightKatja M Gist
Jun 2, 2017·Experimental and Therapeutic Medicine·Jiachang HuXiaoqiang Ding
Apr 1, 2020·Archives of Physiology and Biochemistry·Nisha SharmaAnil Bhanudas Gaikwad
Nov 20, 2016·Digestive Diseases and Sciences·Larisse Tavares LucettiMarcellus Henrique Loiola Ponte Souza
Jul 4, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Sook Kyung YumIn Kyung Sung
Feb 6, 2021·Journal of Personalized Medicine·Babita Shashni, Yukio Nagasaki

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