Metabolic acidosis lowers circulating adiponectin through inhibition of adiponectin gene transcription

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Sinee DisthabanchongSuradej Hongeng

Abstract

Metabolic acidosis (MA) adversely affects protein and lipid metabolism as well as endocrine function. Adipose tissue communicates with the rest of the body through synthesis and release adipokines, such as leptin, adiponectin and TNF-alpha. Adiponectin enhances insulin sensitivity and possesses anti-atherogenic and anti-inflammatory properties. Circulating adiponectin correlates inversely with cardiovascular events. It is possible that MA negatively regulates adiponectin contributing to poor patient outcome. The present study investigates the effect of MA on adiponectin in vivo and in vitro. Twenty healthy female volunteers underwent a 7-day course of oral ammonium chloride (NH4Cl)-induced acidosis. Serum adiponectin was determined before and after NH4Cl ingestion. Adipocytes were differentiated from their precursors, human mesenchymal stem cells (hMSCs), in culture. Concentrated HCl was added to the media to lower pH. Adiponectin mRNA and protein were determined at 48 and 96 h by real-time RT-PCR and ELISA, respectively. After a 7-day course of NH4Cl, serum bicarbonate decreased significantly associated with the increase in urine ammonium and titratable acid. Adiponectin decreased significantly from 10,623 to 9723 pg/mL (P<0.0...Continue Reading

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Citations

May 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ana Rodríguez-CarmonaFernando Cordido
Aug 3, 2012·Nutrition & Metabolism·Ian Forrest Robey
Jan 1, 2010·International Journal of Molecular Sciences·Kawin LeelawatSuradej Hongeng
Sep 18, 2012·Biochimie·Ting JiaPeter Stenvinkel
Sep 7, 2011·Biochemical and Biophysical Research Communications·Truc P T PhamJaekyoon Shin
Sep 4, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Ana Rodríguez-CarmonaFernando Cordido
Sep 25, 2018·International Journal of Cancer. Journal International Du Cancer·Yong-Moon Mark ParkDale P Sandler
Oct 23, 2020·Public Health Nutrition·Saeede Jafari NasabAmir Sadeghi
Feb 24, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Li-Wei ShiGuo-Chao Zhong
Sep 10, 2021·Open Heart·James J DiNicolantonio, James H O'Keefe

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