PMID: 9659366Jul 11, 1998Paper

Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects

Biochimica Et Biophysica Acta
Juan Segura-AguilarC J Welch

Abstract

In this study, it is shown that considerable evidence for the possible pathway by which dopamine o-quinone, o-quinone and aminochrome can be activated metabolically by NADPH cytochrome P450 reductase to high reactive semiquinones. These findings were discussed from a mechanistic standpoint as well as in terms of potential physiological implications of dopamine o-quinones and o-semiquinones' concerted action in oxidative stress and apoptotic events.

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Citations

Jul 25, 2000·Biochemical and Biophysical Research Communications·A Dagnino-SubiabreJ Segura-Aguilar
Feb 22, 2001·Biochemical and Biophysical Research Communications·S HaradaY Kawanishi
May 18, 2001·Biochemical and Biophysical Research Communications·P Martinez-AlvaradoJ Segura-Aguilar
Jan 11, 2005·Neurotoxicity Research·Juan Segura Aguilar, Richard M Kostrzewa
Jun 16, 2009·Neurotoxicity Research·Irmgard ParisJuan Segura-Aguilar
Nov 20, 2003·Brain Research·José Cláudio F MoreiraJoão Antonio Pêgas Henriques
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Gabriela Díaz-VélizJuan Segura-Aguilar
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·G Díaz-VélizJ Segura-Aguilar
Jan 16, 1999·Free Radical Biology & Medicine·D MetodiewaJ Segura-Aguilar
Jun 28, 2003·Neurotoxicity Research·J Segura-AguilarM Herrera-Marschitz
Mar 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Irmgard ParisJuan Segura-Aguilar
Mar 19, 2008·Photochemistry and Photobiology·Walter A MassadNorman A García
Sep 12, 2012·Parkinson's Disease·Patricia MuñozJuan Segura-Aguilar
Feb 4, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Pabla AguirreMarco T Núñez
Oct 3, 2006·Expert Review of Neurotherapeutics·Masato Asanuma, Ikuko Miyazaki
Jan 5, 2002·Expert Opinion on Investigational Drugs·B Drukarch, F L van Muiswinkel
Aug 12, 2009·Expert Opinion on Drug Metabolism & Toxicology·Seong-Ho KohHee-Tae Kim
Aug 5, 2008·Free Radical Biology & Medicine·Q MichardB A Bernard
May 6, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ju Hee LimHyun Jin Choi
May 22, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zunzhen ZhangDesheng Wu
Oct 13, 2015·Progress in Neurobiology·Fabio A ZuccaLuigi Zecca
Feb 20, 2014·Journal of Neurochemistry·Juan Segura-AguilarFabio A Zucca
Mar 24, 2016·Cellular and Molecular Life Sciences : CMLS·Andrea HerreraJuan Segura-Aguilar

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