Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas

Clinical Nuclear Medicine
Winnie K S ChanPek-Lan Khong

Abstract

We aim to compare the metabolic activity by F-18 fluorodeoxyglucose (FDG) uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) in a single center, with particular interest in the natural killer (NK)-cell lymphoma subtype for which literature is scarce because of the rarity of these lymphomas in Western populations. We retrospectively evaluated the FDG-avidity of pretreatment positron emission tomography-computed tomography scans of 117 consecutive NHL patients by measuring the lesion with the highest maximum standardized uptake value (SUV(max)) in each patient. Mean SUV(max) of 4 major groups of NHL; aggressive B-cell (n = 63), indolent B-cell (n = 31), NK-cell (n = 14) and aggressive T-cell lymphoma (n = 9), was compared using one-way analysis of variance. P value <0.05 was considered statistically significant. SUV(max) (mean +/- standard deviation) of NK-cell lymphoma (9.2 +/- 4.5) was significantly lower than aggressive B-cell lymphoma (14.1 +/- 6.4) (P = 0.013), similar to aggressive T-cell lymphoma (7.6 +/- 3.9) and significantly higher than that of indolent B-cell lymphoma (5.3 +/- 3.1) (P = 0.039). The metabolic phenotype, characterized by FDG uptake of the various NHL subtypes is described. Althou...Continue Reading

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Citations

Jul 12, 2011·Current Opinion in Oncology·Arnaud Jaccard, Olivier Hermine
Jun 14, 2012·Current Opinion in Oncology·Eric Tse, Yok-Lam Kwong
Sep 6, 2011·Clinical Nuclear Medicine·Thorsten DerlinSusanne Klutmann
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