Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines.

Current Opinion in Pharmacology
Justine FaramiaAndré Tchernof

Abstract

This review addresses the impact of bariatric surgery on the endocrine aspects of white adipose tissue, muscle and the liver. We describe literature supporting the notion that adipokines, myokines and hepatokines likely act in concert and drive many of the long-term metabolic improvements following surgery. Circulating adiponectin is increased while secretion of pro-inflammatory interleukins (1, 6 and 8) decreases, alongside leptin secretion. The metabolic improvements observed in the muscle might relate to reduction of myokines contributing to insulin resistance (including myostatin, brain-derived neurotrophic factor and fibroblast growth factor-21). Subject to exception, hepatokine secretion is generally increased (such as insulin-like growth factor-binding protein 2, adropin and sex hormone-binding globulin). In conclusion, bariatric surgery restores metabolic functions by enhancing the time-dependent secretion of anti-inflammatory, insulin-sensitizing and antilipemic factors. Further research is needed to understand the molecular mechanisms by which these factors may trigger the remission of obesity-related comorbidities following bariatric surgery.

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Citations

Nov 29, 2020·Metabolism: Clinical and Experimental·Marie-Eve PichéPaul Poirier
Apr 4, 2021·International Journal of Molecular Sciences·Ana Rita de Oliveira Dos SantosJesselina F Dos Santos Haber

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